Impairment of glyoxalase-1, an advanced glycation end-product detoxifying enzyme, induced by inflammation in age-related osteoarthritis

Accumulation of advanced glycation end-products (AGEs) is involved in age-related osteoarthritis (OA). Glyoxalase (Glo)-1 is the main enzyme involved in the removal of AGE precursors, especially carboxymethyl-...

Source: Arthritis Research and Therapy - January 11, 2019 Category: Rheumatology Authors: Sabine Trellu, Alice Courties, St éphane Jaisson, Laëtitia Gorisse, Philippe Gillery, Saadia Kerdine-Römer, Carlos Vaamonde-Garcia, Xavier Houard, François-Paul Ekhirch, Alain Sautet, Bertrand Friguet, Claire Jacques, Francis Berenbaum and Jérémie S Tags: Research article Source Type: research