Can AI Really Be a Game Changer in Cervical Cancer Screenings?

An artificial intelligence solution (AI) can accurately identify precancerous changes that could require medical attention in images from a woman’s cervix. Researchers from the National Institutes of Health and Global Good developed the computer algorithm, which is called automated visual evaluation. Researchers created the algorithm by using more than 60,000 cervical images from a National Cancer Institute (NCI) archive of photos collected during a cervical cancer screening study that was carried out in Costa Rica in the 1990s. More than 9,400 women participated in that population study, with follow up that lasted up to 18 years. Because of the prospective nature of the study, the researchers said that they gained nearly complete information on which cervical changes became pre-cancers and which did not. Researchers said the photos were then digitized and used to train a deep learning algorithm so that it could distinguish cervical conditions requiring treatment from those not requiring treatment. "Our findings show that a deep learning algorithm can use images collected during routine cervical cancer screening to identify precancerous changes that, if left untreated, may develop into cancer," Mark Schiffman, M.D., M.P.H., of NCI's Division of Cancer Epidemiology and Genetics, and senior author of the study, said in a release. "In fact, the computer analysis of the images was better at identifying pre-cancer than a human expert reviewer of Pa...
Source: MDDI - Category: Medical Devices Authors: Tags: Software Imaging Source Type: news

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ConclusionsOur study reveals the need for targeted patient ‐education about the benefits and limitations of follow‐up. In order to meet increasing costs of cancer care, individualized follow‐up procedures adjusted to risk of recurrence and late‐effects in cervical cancer survivors are warranted.
Source: Acta Obstetricia et Gynecologica Scandinavica - Category: OBGYN Authors: Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
AbstractAimThe present study was designed with the aim to predict Pap smear screening beliefs based on Big Five personality traits.DesignThe present cross ‐sectional study was conducted with 235 women over 18 years of age in Tehran (Iran) in 2018.MethodsThe data collection tools included the demographic information questionnaire, Pap Smear Belief Questionnaire (PSBQ) and the 10 ‐item measure of the Big Five personality traits.ResultsPeople with Agreeableness personality trait were more faced with risks and Barriers and factors associated with Pap smear screening beliefs; and those with Conscientiousness personalit...
Source: Nursing Open - Category: Nursing Authors: Tags: RESEARCH ARTICLE Source Type: research
In this study, we report the first-ever clinically occult OPC in an asymptomatic patient discovered through a saliva test. This case relied upon serial measurements of HPV-16 DNA in saliva, which fell to undetectable levels following low morbidity, curative treatment.
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
rrera-Saldaña María L. Garza-Rodríguez Persistent high-risk human papillomavirus (HR-HPV) infections play a major role in the development of invasive cervical cancer (CC), and screening for such infections is in many countries the primary method of detecting and preventing CC. HPV typing can be used for triage and risk stratification of women with atypical squamous cells of undetermined significance (ASC-US)/low-grade cervical lesions (LSIL), though the current clinical practice in Mexico is to diagnose CC or its preceding conditions mainly via histology and HR-HPV detection. Additional informati...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
AbstractObjectiveThis paper aimed to discuss the scope of operation and clinical effects for locally advanced cervical cancer (LACC) after concurrent chemoradiotherapy (CCRT).MethodsWe retrospectively reviewed the records of 444 patients with stages IB2 –IIB cervical cancer who were divided into two groups whether or not they received CCRT before radical operation in our institute from January 2013 to December 2016. Patients’ characteristics, treatments, and outcomes were analyzed.ResultsThe total efficiency (CR  + PR) of the CCRT + operation group was 96.2%. Specifically, the CR rat...
Source: International Journal of Clinical Oncology - Category: Cancer & Oncology Source Type: research
Source: Cancer Management and Research - Category: Cancer & Oncology Tags: Cancer Management and Research Source Type: research
Publication date: Available online 12 March 2020Source: Biomedicine &PharmacotherapyAuthor(s): Hongning Cai, Lin Yan, Nian Liu, Meng Xu, Hongbing Cai
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
This study aimed to evaluate the clinical value of HR-HPV viral loads to predict the residual/recurrence lesions among women with high-grade squamous lesions or worse ( ≥ HSIL) after surgery. Finally, 301 women who underwent primary screening of cervical cancer using polymerase-chain-reaction-(PCR)-reverse-dot-blot-(RDB) human papillomavirus (HPV) genotyping and cytology assays were enrolled. They received surgery and took HR-HPV viral loads with a BioPerfectus Multiplex Real-Time PCR assay. Colposcopy biopsies were performed in patients with HPV-16/18(+) and/or TCT ≥ ASCUS with HR-HPV(+). The ri...
Source: Medical Oncology - Category: Cancer & Oncology Source Type: research
Authors: Lu F, Cui D, Mu B, Zhao L, Mu P Abstract Tropomodulin-1 (TMOD1) is a key regulator of actin dynamics, which caps the pointed end of actin filaments. TMOD1 has been reported to be involved in several cellular processes, including neurite outgrowth, spine formation and cell migration. Increasing evidence demonstrates that TMOD1 is implicated in several aspects of cancer development. The present study aimed to investigate the role of TMOD1 in cervical cancer. HeLa and CaSki cell lines, derived from human cervical cancer, were used to evaluate the function of TMOD1. Cell motility was measured via a wound-heali...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
Many papers and reviews have described the changes of the cervix during pregnancy, cervical cancer, sexually transmitted infections, and cervicovaginal microbiota. In this Views and Reviews, we focus on some specific topics in relation to the uterine cervix and infertility: early cervical cancer and fertility sparing surgery, cesarean scar defect, cervical incompetence, and cervical m üllerian anomalies.
Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Tags: Views and reviews Source Type: research
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