Lilly eyes more cancer deals, but wary of CAR-T, gene therapy

Eli Lilly and Co remains in the hunt for cancer drugs even after announcing an $8 billion purchase of Loxo Oncology this week, but it plans to remain on the sidelines when it comes to two of the hottest areas of drug development.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news

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Prognostic significance of PAK family kinases in acute myeloid leukemia, Published online: 20 March 2019; doi:10.1038/s41417-019-0090-1Prognostic significance of PAK family kinases in acute myeloid leukemia
Source: Cancer Gene Therapy - Category: Cancer & Oncology Authors: Source Type: research
ConclusionOur results reveal that circRNAs may play a role in NSCLC AZD9291 resistance and might be a promising molecular target candidate for gene therapy.
Source: Thoracic Cancer - Category: Cancer & Oncology Authors: Tags: ORIGINAL ARTICLE Source Type: research
Publication date: Available online 12 March 2019Source: Journal of Industrial and Engineering ChemistryAuthor(s): Jieun Han, Kun NaAbstractFor effective gene therapy using Tumor necrosis factor-Related Apoptosis-Inducing Ligand (TRAIL), which is a protein that selectively induces cancer cell apoptosis through mesenchymal stem cells (hMSCs), low cytotoxicity branched polyethyleneimine (bPEI) 25k carbon dots (bPEI25k CDs) were investigated as a TRAIL-GFP gene (plasmid TRAIL-GFP, pTRAIL-GFP) carrier for delivery into hMSCs. bPEI25k CDs were prepared using one-step microwave-assisted pyrolysis, which has the advantage of low c...
Source: Journal of Industrial and Engineering Chemistry - Category: Chemistry Source Type: research
Reviewer Recognition, Published online: 13 March 2019; doi:10.1038/s41417-019-0088-8Reviewer Recognition
Source: Cancer Gene Therapy - Category: Cancer & Oncology Source Type: research
Human Gene Therapy, Ahead of Print.
Source: Human Gene Therapy - Category: Genetics & Stem Cells Authors: Source Type: research
A novel approach for assessment of prostate cancer aggressiveness using survivin-driven tumour-activatable minicircles, Published online: 13 March 2019; doi:10.1038/s41434-019-0067-6A novel approach for assessment of prostate cancer aggressiveness using survivin-driven tumour-activatable minicircles
Source: Gene Therapy - Category: Genetics & Stem Cells Authors: Source Type: research
In this study, a novel delivery synthesized by PEG-PCL-PEG and DOTAP (PPPD) was applied to encapsulate MP plasmids to derive the advantage and overcome the drawback of VSV platform in the treatment of colon cancer. The MP/DPPP micelles were stable in physiological solution, with an average diameter of 102 nm and zeta potential of 5.4 mV. This delivery system has a high encapsulation rate of 96% and transfection efficiency of 36%. A prominent anti-cancer activity of MP/DPPP was found both in Ct26 cells and animal models. The mechanisms of antitumor were further explored in this research. Our results indicated that MP/DPPP m...
Source: Polymer - Category: Chemistry Source Type: research
Role of tumor‑derived extracellular vesicles in cancer progression and their clinical applications (Review). Int J Oncol. 2019 Mar 12;: Authors: Qiao F, Pan P, Yan J, Sun J, Zong Y, Wu Z, Lu X, Chen N, Mi R, Ma Y, Ji Y Abstract Extracellular vesicles (EVs), including micro‑vesicles and exosomes, are heterogeneous small membranous vesicles shed from the surface of myriad cells and are crucial in mediating intercellular communication. The vertical trafficking of cargo to the plasma membrane and subsequent redistribution of surface lipids may contribute to EV formation. Tumor‑derived extracellular ...
Source: International Journal of Oncology - Category: Cancer & Oncology Authors: Tags: Int J Oncol Source Type: research
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
This study will thus help biomedical researchers in tapping the potential of CQDs to overcome various existing technological challenges.Graphical abstractMultimodal Biomedical Applications of CQDs
Source: Biosensors and Bioelectronics - Category: Biotechnology Source Type: research
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