Knowledge, attitudes and practice of physicians towards fertility and pregnancy-related issues in young BRCA-mutated breast cancer patients: results from the BCY3/BCC 2017 survey

Publication date: Available online 10 January 2019Source: Reproductive BioMedicine OnlineAuthor(s): Matteo Lambertini, Massimo Di Maio, Francesca Poggio, Olivia Pagani, Giuseppe Curigliano, Lucia Del Mastro, Shani Paluch-Shimon, Sibylle Loibl, Ann H. Partridge, Jr. Hatem A. Azim, Fedro A. Peccatori, Isabelle DemeestereABSTRACTResearch questionWe explored the knowledge, attitudes and practice of physicians towards fertility and pregnancy-related issues in young BRCA-mutated breast cancer (BC) patients.DesignPhysicians attending two international BC conferences were asked to complete a 26-item questionnaire exploring fertility preservation, pregnancy during (BCP) or after BC. A statistical comparison for the responses obtained from the questions exploring the same issues in young BC patients overall or specifically in those with BRCA mutations was performed.ResultsThe survey was completed by 273 physicians. Ovarian tissue cryopreservation (33% vs. 40%; p=0.009) and GnRHa during chemotherapy (74% vs. 81%; p=0.001) were less commonly suggested in BRCA-mutated patients than in the overall BC population. 42% of the respondents agreed or were neutral on the statement that controlled ovarian stimulation should not be considered safe in BRCA-mutated BC patients. 45% and 30% agreed or were neutral on the statement that pregnancy in BC survivors may increase the risk of recurrence in BRCA-mutated patients or in the overall BC population, respectively (p
Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research

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Abstract Breast cancer (BC) is the most common malignancy in women with a significant increasing incidence during the reproductive life. However, based on the newest anti-cancer molecular targeting drugs, successful treatments lead to the disease healing particularly in young patients, thus refreshing their motherhood programs. However, as effect of the BC treatment, a premature depletion of the ovarian follicle reserve occurs in more than one-third of patients resulting in permanent infertility. To prevent the cancer treatment-related infertility (CTRI), several options are today utilized. Besides the ovary suppr...
Source: Clinical Breast Cancer - Category: Cancer & Oncology Authors: Tags: J Cancer Res Clin Oncol Source Type: research
AbstractBreast cancer (BC) is the most common malignancy in women with a significant increasing incidence during the reproductive life. However, based on the newest anti-cancer molecular targeting drugs, successful treatments lead to the disease healing particularly in young patients, thus refreshing their motherhood programs. However, as effect of the BC treatment, a premature depletion of the ovarian follicle reserve occurs in more than one-third of patients resulting in permanent infertility. To prevent the cancer treatment-related infertility (CTRI), several options are today utilized. Besides the ovary suppression by ...
Source: Journal of Cancer Research and Clinical Oncology - Category: Cancer & Oncology Source Type: research
RARITAN, N.J., February 3, 2020 – The Janssen Pharmaceutical Companies of Johnson &Johnson announced today multiple data presentations from a robust solid tumor portfolio that will be featured at the American Society of Clinical Oncology Genitourinary (ASCO GU) Cancers Symposium, taking place February 13-15 in San Francisco. Company-sponsored data presentations will include clinical results for ERLEADA® (apalutamide) and niraparib in prostate cancer; and BALVERSA™ (erdafitinib) in bladder cancer. “We are committed to improving outcomes in patients with prostate and bladder cancer where high unmet ...
Source: Johnson and Johnson - Category: Pharmaceuticals Tags: Innovation Source Type: news
AbstractPurpose of ReviewYoung women represent a minority of breast cancer patients for which fertility, family planning, and pregnancy represent unique vulnerabilities. This review intends to discuss recent published evidence regarding treatment-related infertility, fertility counseling, and preservation.Recent FindingsFertility concerns are common among young women with breast cancer and may negatively affect treatment decisions. Data is available to aid providers in approximating odds of post-treatment amenorrhea and infertility. Multiple fertility preservation techniques are available. While embryo preservation is most...
Source: Current Breast Cancer Reports - Category: Cancer & Oncology Source Type: research
ConclusionsWomen with an early stage of breast cancer and a possible future child wish should be referred to an expertise center in breast cancer, fertility preservation, and genetics in this complex decision-making process, shortly after diagnosis.
Source: Journal of Assisted Reproduction and Genetics - Category: Reproduction Medicine Source Type: research
Spécificités du traitement médicamenteux antihypertenseur chez la femme. Presse Med. 2019 Nov 14;: Authors: Amar J, Angoulvant T, Boivin JM, Amar L, Lantelme P, Blacher J, Plu-Bureau G, Vehier CM Abstract The impact of antihypertensive drugs on blood pressure does not differ according to the sex. There are women-specific conditions or medical conditions encountered more frequently among womens that guide the selection of therapy such as a desire to become pregnant, a pregnancy, a polycystic ovarian syndrome, breast cancer, osteoporosis or migraine. PMID: 31735525 [PubMed - as...
Source: Presse Medicale - Category: General Medicine Authors: Tags: Presse Med Source Type: research
ConclusionsThis case reports shows that MNC IVF conception after OTC is successful in patients with tissue partially placed in a peritoneal window. If the tissue placed in the peritoneal window becomes active, MNC IVF can be performed. If the tissue placed in the remaining ovary becomes active, natural conception should be pursued.
Source: Case Reports in Womens Health - Category: OBGYN Source Type: research
Conclusions: A close collaboration between Cancer and Fertility Center in a tertiary care hospital is essential to provide a good health service in oncological patients. Offering fertility preservation is no longer considered optional and must be included in every therapeutic program for women who receive an oncological diagnosis in their reproductive age. Oocyte cryopreservation is a good option for fertility preservation for women facing cancer treatment and our results, despite on a small sample, are encouraging. We also confirm a low utilization rate as only 4.5% of patients returned to use their gametes.
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
FERTILITY PRESERVATION IN YOUNG WOMEN WITH EARLY-STAGE BREAST CANCER. Acta Clin Croat. 2019 Mar;58(1):147-156 Authors: Vuković P, Kasum M, Raguž J, Lonjak N, Bilić Knežević S, Orešković I, Beketić Orešković L, Čehić E Abstract Although breast cancer (BC) occurs more often in older women, it is the most commonly diagnosed malignancy in women of childbearing age. Owing to the overall advancement of modern medicine and the growing global trend of delaying childbirth until later age, we find ever more younger women diagnosed and treated for BC who have not yet completed their family...
Source: Acta Clinica Croatica - Category: General Medicine Tags: Acta Clin Croat Source Type: research
[Thomson Reuters Foundation] Kuala Lumpur -Breastfeeding can help prevent diarrhea and pneumonia, two major causes of infant death, and protect mothers against ovarian and breast cancer
Source: AllAfrica News: Pregnancy and Childbirth - Category: OBGYN Source Type: news
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