Parasites from patients with cerebral malaria stick preferentially in their brains

(Liverpool School of Tropical Medicine) A team at LSTM with their collaborators in Malawi and Denmark have provided, for the first time, evidence which links the ability of red blood cells infected with the malaria parasite to bind to the cells lining the blood vessels of the brain, with the clinical syndrome cerebral malaria.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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Conclusion:   CoBaT-Y017 presented a significant safety and tolerability in healthy volunteers to allow its further development by starting a phase II clinical study. PMID: 31118966 [PubMed]
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Publication date: Available online 23 May 2019Source: Journal of Theoretical BiologyAuthor(s): Winston Garira, Dephney MathebulaAbstractIn this paper, we share with the biomathematics community a new coupled multiscale model which has the potential to inform policy and guide malaria control and elimination. The formulation of this multiscale model is based on integrating four submodels which are: (i) a sub-model for the mosquito-to-human transmission of malaria parasite, (ii) a sub-model for the human-to-mosquito transmission of malaria parasite, (iii) a within-mosquito malaria parasite population dynamics sub-model and (i...
Source: Journal of Theoretical Biology - Category: Biology Source Type: research
Elimination of malaria depends on mastering transmission and understanding the biological basis of Plasmodium infection in the vector. The first mosquito organ to interact with the parasite is the midgut and its ...
Source: Parasites and Vectors - Category: Microbiology Authors: Tags: Research Source Type: research
Infections that reach the placenta via maternal blood target the fetal-placental barrier and are associated with reduced birth weight, increased stillbirth, miscarriage and perinatal mortality. Malaria during pregnancy can lead to infection of the placental tissue with adverse effects on the unborn child even if the parasite is successfully cleared, indicating that placental sufficiency is significantly compromised. Human samples and animal models of placental malaria have been used to unravel mechanisms contributing to this insufficiency and have implicated molecular pathways related to inflammation, innate immunity and n...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
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Source: Parasites and Vectors - Category: Microbiology Authors: Tags: Research Source Type: research
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Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
;ttcher T Abstract Expanding the chemical space of quinolones led to a tandem quinolone-alkyne-cyclisation reaction allowing chemoselective control of the synthesis of tricyclic pyrrolo[1,2-a]quinolin-5-ones. Importantly, we discovered anti-protozoal activity against Plasmodium and Toxoplasma with specific potency of one of the compounds against the liver stage of the malaria parasite in the nanomolar range. PMID: 31119221 [PubMed - as supplied by publisher]
Source: Chemical Communications - Category: Chemistry Authors: Tags: Chem Commun (Camb) Source Type: research
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Source: Cochrane Database of Systematic Reviews - Category: General Medicine Authors: Tags: Cochrane Database Syst Rev Source Type: research
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Source: Korean Journal of Parasitology - Category: Parasitology Tags: Korean J Parasitol Source Type: research
The intensive use of chemical insecticides against mosquitoes has led to the development of widespread insecticide resistance. Control of Anopheles mosquitoes in malaria endemic areas of sub-Saharan Africa has be...
Source: Parasites and Vectors - Category: Microbiology Authors: Tags: Research Source Type: research
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