Monkeypox re-emergence in Africa: a call to expand the concept and practice of One Health.

Monkeypox re-emergence in Africa: a call to expand the concept and practice of One Health. Expert Rev Anti Infect Ther. 2019 Jan 09;: Authors: Reynolds MG, Doty JB, McCollum AM, Olson VA, Nakazawa Y Abstract INTRODUCTION: Monkeypox is a re-emerging viral zoonosis that occurs naturally in heavily-forested regions of West and Central Africa. Inter-human transmission of monkeypox virus, although limited, drives outbreaks, particularly in household and healthcare settings. But the available evidence suggests that without repeated zoonotic introductions, human infections would eventually cease to occur. Therefore, interrupting virus transmission from animals to humans is key to combatting this disease. Such efforts, however, are hindered by an incomplete understanding of the maintenance and transmission dynamics of the virus in its natural reservoir host(s). Areas covered: Herein we review laboratory and field studies examining the susceptibility of various animal taxa to monkeypox virus infection, and note the competence of various species to serve as reservoirs or transmission hosts. In addition, we discuss early socio-ecologic theories of monkeypox virus transmission in rural settings and review current modes of ecologic investigation-including ecologic niche modeling, and ecologic sampling-in light of their potential to identify specific animal species and features of the environment that are associated with heightened risk for human ...
Source: Expert Review of Anti-Infective Therapy - Category: Infectious Diseases Tags: Expert Rev Anti Infect Ther Source Type: research