Central Obesity Linked to Lower Brain Volumes Central Obesity Linked to Lower Brain Volumes

Carrying extra body fat, especially around the middle, is linked to lower gray matter volumes, a new study shows, raising the possibility that controlling obesity may reduce future dementia risk.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Neurology & Neurosurgery News Source Type: news

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Metabolic Syndrome (MetS), also known as syndrome X, insulin resistance syndrome, or dysmetabolic syndrome (ICD-9 code 277.7) is a cluster of metabolic risk factors that come together in a single individual.1,2 These factors include (1) abdominal obesity, (2) hypertriglyceridemia, (3) low high-density lipoprotein (HDL), (4) hypertension, and (5) hyperglycaemia with insulin resistance.3,4 Even if the MetS construct has been criticized over the last decades,5,6 the increasing worldwide prevalence of obesity and unhealthy life-styles turned on the spotlight on MetS as a severe public health issue,3 prompting research on this topic.
Source: The American Journal of Geriatric Psychiatry - Category: Geriatrics Authors: Tags: Clinical Review Article Source Type: research
This study, as well as other research on the connection between diet beverages and vascular disease, is observational and cannot show cause and effect. That’s a major limitation, researchers say, as it’s impossible to determine whether the association is due to a specific artificial sweetener, a type of beverage or another hidden health issue. “Postmenopausal women tend to have higher risk for vascular disease because they are lacking the protective effects of natural hormones,” North Carolina cardiologist Dr. Kevin Campbell said, which could contribute to increased risk for heart disease and stroke...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Health News CNN Heart Attack Stroke Source Type: news
This study, as well as other research on the connection between diet beverages and vascular disease, is observational and cannot show cause and effect. That’s a major limitation, researchers say, as it’s impossible to determine whether the association is due to a specific artificial sweetener, a type of beverage or another hidden health issue. “Postmenopausal women tend to have higher risk for vascular disease because they are lacking the protective effects of natural hormones,” North Carolina cardiologist Dr. Kevin Campbell said, which could contribute to increased risk for heart disease and stroke...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Health News CNN Heart Attack Stroke Source Type: news
CONCLUSION: The major limitation was the use of the same medical conditions to measure multimorbidity and disease severity. Other studies and analysis models should explore the complexity of the multimorbidity phenomenon. PMID: 30753802 [PubMed - in process]
Source: Acta Medica Portuguesa - Category: General Medicine Tags: Acta Med Port Source Type: research
We report that the bone marrow stromal cell senescence is driven by p16INK4a expression. The p16INK4a-expressing senescent stromal cells then feedback to promote AML blast survival and proliferation via the SASP. Importantly, selective elimination of p16INK4a-positive senescent bone marrow stromal cells in vivo improved the survival of mice with leukemia. Next, we find that the leukemia-driven senescent tumor microenvironment is caused by AML induced NOX2-derived superoxide. Finally, using the p16-3MR mouse model we show that by targeting NOX2 we reduced bone marrow stromal cell senescence and consequently reduced A...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Only a third of respondents knew that it ’s a health condition they can reduce their chances of developing Related items fromOnMedica Scotland reveals target of halving child obesity by 2030 Prioritise and fund prevention to save lives and NHS, warn doctors Social prescribing can free up GPs ’ time and save resources GP leaders welcome U-turn on dementia payments Maternity care better in some respects – but still many problems
Source: OnMedica Latest News - Category: UK Health Source Type: news
Abstract The females of most species die soon after ceasing to reproduce, their purpose in life being to ensure survival of their kin. Human females may live more than one-third of their lives after they cease to reproduce, a property shared by few species, one of which is Orca whales. Orcas have been extensively studied because families live together in stable units or pods and individual whales have distinctive markings, enabling them to be identified. The females survive long after the menopause, one possible reason for this being that the older females provide a survival advantage since they are seen to lead t...
Source: Climacteric - Category: Geriatrics Authors: Tags: Climacteric Source Type: research
In this study, we examined the benefits of early-onset, lifelong AET on predictors of health, inflammation, and cancer incidence in a naturally aging mouse model. Lifelong, voluntary wheel-running (O-AET; 26-month-old) prevented age-related declines in aerobic fitness and motor coordination vs. age-matched, sedentary controls (O-SED). AET also provided partial protection against sarcopenia, dynapenia, testicular atrophy, and overall organ pathology, hence augmenting the 'physiologic reserve' of lifelong runners. Systemic inflammation, as evidenced by a chronic elevation in 17 of 18 pro- and anti-inflammatory cytokin...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Being physically fit is very much better for long term health than being unfit. But in this era of cheap and attractive calories, it is quite possible to be both physically fit and overweight to some degree. Many people are. Unfortunately, being fit doesn't meaningfully protect against the detrimental effects of excess fat tissue on health and disease risk. If you are carrying more visceral fat tissue, then you have a higher risk of all of the common age-related diseases, when compared with someone of the same level of fitness with less visceral fat tissue. Not so many years ago, metrics based on the ratio of height...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs
In this study, we assessed the presence of a correlat ion between plasma VIS level and insulin resistance or AD. Sixty participants were enrolled in this study; 34 patients with AD and 26 healthy subjects. All subjects underwent comprehensive evaluations including Mini-mental score exam (MMSE) for the diagnosis of dementia. Subjects with MMSE score  27. Fasting blood sugar (FBS) and insulin levels were measured by enzyme-linked immunosorbent assay. The results indicate a significant elevation in FBS from 103 ± 3.0 to 147 ± 7.6 in AD patients (p ≤ 0.001). Add...
Source: Acta Neurologica Belgica - Category: Neurology Source Type: research
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