Driving High Common in Pain Patients Taking Medical Marijuana Driving High Common in Pain Patients Taking Medical Marijuana

Driving under the influence of cannabis is common among patients prescribed medical marijuana for chronic pain, in findings investigators describe as'concerning. 'Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Psychiatry News Source Type: news

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There is a dire need for new non-opioid analgesics. However, efforts to develop new pain medicines have thus far met with limited success. This failure is partly due to an overreliance on evoked pain measures in preclinical models. Most preclinical models  do not measure spontaneous pain—the main symptom of chronic pain in humans. Here we show our progress towards developing and validating a fully-automated and user-friendly spontaneous pain measurement tool by training a machine learning model to detect and quantify facial grimacing in mice.
Source: The Journal of Pain - Category: Materials Science Authors: Source Type: research
The management of chronic pain with opioids can cause opioid-induced analgesic tolerance (OIT) and hyperalgesia (OIH), which complicates clinical pain-management treatments. Although G-protein coupled receptors have been studied for years, the intracellular signaling pathways triggered by the activation of µ-opioid receptors are not well known. We sought to determine whether OIT is linked to a decreased activity in the PI3K/AKT intracellular signaling pathway. To assess this pathway, 25 C57BL/6 WT male mice (21 ± 4g) were divided into control (n=10, 1 μL saline) and experimental (n=10, 15 mg/kg of morphine;...
Source: The Journal of Pain - Category: Materials Science Authors: Source Type: research
We describe here a conditional GluN2B KO mouse used to assess the role of GluN2B subunits on agmatine's electrophysiological responses in spinal cord dorsal horn.
Source: The Journal of Pain - Category: Materials Science Authors: Source Type: research
Telomere length, a measure of cellular aging, is negatively associated with chronic pain severity and serves as an indicator of overall system functioning.  While psychological resilience factors such as optimism, acceptance, positive affect and active coping have been associated with lower levels of clinical pain and greater physical functioning, it is unknown whether resilience may buffer against telomere shortening in individuals with chronic pain. Additionally, a broader conceptualization of resilience that includes biobehavioral and social factors may improve our understanding of the relationship between resilien...
Source: The Journal of Pain - Category: Materials Science Authors: Source Type: research
Patients with sickle cell disease (SCD) experience severe acute pain episodes, and often progress to chronic pain. In patients with chronic pain, microglia are readily activated, stimulating neurons to send a pain signal; studying microglia may provide important insights into development of chronic pain. Human microglia are difficult to obtain; we proposed to culture microglia-like cells (MLC) from peripheral blood from three individuals from each of the following groups: patients with SCD and chronic pain (SCD CP+, defined as pain for more than 50% of days for at least 3 months), without chronic pain (SCD CP-), and blood donors (WT).
Source: The Journal of Pain - Category: Materials Science Authors: Source Type: research
Chronic musculoskeletal pain (MSP) is common following traumatic or stressful life events and is more common in women than men. However, female specific predictors and mediators of chronic posttraumatic MSP are poorly understood. In the current study we examined the relationship between circulating 17 β-estradiol (E2) levels, RNA transcripts that E2 might influence, and chronic MSP development in women following traumatic motor vehicle collision (MVC) without fractures/tissue injury. Blood plasma and RNA was collected from individuals enrolled in the emergency department (ED) following MVC traum a and MSP severity (0-...
Source: The Journal of Pain - Category: Materials Science Authors: Source Type: research
Considering the opioid epidemic, safe alternatives to opioids for pain management is paramount. Effective non-pharmacological management of chronic pain requires individuals  to initiate and maintain healthy behavior changes over time. To facilitate behavioral change, an in-depth understanding of mechanisms of action underlying the intervention is required. Supported by the National Institutes of Health (NIH) Common Fund, the Science of Behavior Change (SOBC) program seeks to make behavior change research more impactful, targeted, and systematic by promoting a common, mechanism-focused, experimental medicine approac...
Source: The Journal of Pain - Category: Materials Science Authors: Source Type: research
Decision-making in chronic pain care requires synthesizing complex information from many sources. Treatment guidelines have been described as “unclear and confusing,” which can lead to inconsistent pain care, non-clinically relevant information influencing decisions, and perpetuation of racial and socioeconomic disparities. Increased understanding of the factors influencing providers’ treatment decisions and the extent to which prov iders are aware of their decision-making process may help to reduce disparities and improve care.
Source: The Journal of Pain - Category: Materials Science Authors: Tags: Ethical, Legal, Financial, and Education Source Type: research
Nearly 500,000 burn injuries occur annually in the US, and ∼40,000 individuals experience major thermal burn injury (MThBI) requiring hospitalization. Burn injury is capable of causing ongoing, severe pain, however the incidence of persistent opioid use to treat chronic post-burn injury pain has not been assessed. We estimated the incidence of new chronic opioid use among burn survivors using two methods. First, we performed a retrospective study using the Truven MarketScan® claims 1% database from 2001-2016 and calculated persistent opioid use (receipt of ≥1 prescription 90-180 days following MThBI) among indiv...
Source: The Journal of Pain - Category: Materials Science Authors: Source Type: research
Chronic pain in persons living with HIV (PLWH) may be related to alterations in endogenous pain modulatory processes (e.g., high facilitation and low inhibition of nociception) that promote exaggerated pain responses, known as hyperalgesia and central nervous system sensitization. This observational study examined differences in endogenous pain modulatory processes between 59 PLWH with chronic pain, 51 PLWH without chronic pain, and 50 controls without HIV or chronic pain. Quantitative sensory testing for temporal summation (TS) of mechanical and heat pain as well as conditioned pain modulation (CPM) were used to assess en...
Source: The Journal of Pain - Category: Materials Science Authors: Source Type: research
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