Thrombomodulin and interleukin 6 as potential biomarkers of endothelial dysfunction and inflammation after renal transplant

ABSTRACT Introduction: Endothelial dysfunction may contribute to hypercoagulable and inflammation states presents in renal transplant, chronic kidney disease (CKD) and its causes. These disorders can be evaluated by markers, such as thrombomodulin (TM), von Willebrand factor (vWF) and interleukin 6 (IL-6). Objectives: The aim of this study was to assess TM, vWF and IL-6 in renal transplant recipients (RTR) and associate their plasma levels with primary cause of end-stage renal disease (ESRD) and allograft function. Methods: 160 RTR were grouped according to the primary cause of CKD (G1: glomerulopathy; G2: hypertensive nephrosclerosis; G3: diabetic nephropathy; and G4: other causes/unknown etiology); creatinine plasma levels (C1
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - Category: Pathology Source Type: research

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The objective of this Technical Note is to describe our preferred technique for the primary treatment of AC joint instability in the acute and chronic setting. Using 2 free tendon grafts in combination with a cortical button suspensory device combines the advantages of a nonrigid biologic and anatomic AC and coracoclavicular ligament reconstruction while benefiting from the strength of a cortical suspensory device in resisting displacement of the AC joint.
Source: Arthroscopy Techniques - Category: Surgery Source Type: research
Highly trained dogs are better at alerting patients with type 1 diabetes to hyper- and hypoglycemic episodes than previous studies suggest, new UK research indicates.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Diabetes & Endocrinology News Source Type: news
Publication date: Available online 21 January 2019Source: Diabetes &Metabolic Syndrome: Clinical Research &ReviewsAuthor(s): Masoumeh Otaghi, Milad Azami, Ali Khorshidi, Milad Borji, Zainab TardehAbstractBackgroundOne of the most common endocrinopathy in women of reproductive age is polycystic ovary syndrome (PCOS). Recent studies have reported different prevalence of metabolic syndrome (MetS) in women with PCOS. The aim of this study was to determine whether women with PCOS are at an increased risk of MetS.MethodThe present systematic review and meta-analysis study was conducted using preferred reporting items for...
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - Category: Endocrinology Source Type: research
Abstract Background: Vein graft restenosis has an adverse impact on bridge vessel circulation and patient prognosis after coronary artery bypass grafting. Objectives: We used the extravascular supporter α -cyanoacrylate ( α -CA), the local application rapamycin/sirolimus (RPM), and a combination of the two ( α -CA-RPM) in rat models of autogenous vein graft to stimulate vein graft change. The aim of our study was to observe the effect of α -CA, RPM, and α -CA-RPM on vein hyperplasia. Methods: Fifty healthy Sprague Dawley (SD) rats were randomized into the following 5 groups: sham, control, &al...
Source: Arquivos Brasileiros de Cardiologia - Category: Cardiology Source Type: research
Abstract Background: Vein graft restenosis has an adverse impact on bridge vessel circulation and patient prognosis after coronary artery bypass grafting. Objectives: We used the extravascular supporter α -cyanoacrylate ( α -CA), the local application rapamycin/sirolimus (RPM), and a combination of the two ( α -CA-RPM) in rat models of autogenous vein graft to stimulate vein graft change. The aim of our study was to observe the effect of α -CA, RPM, and α -CA-RPM on vein hyperplasia. Methods: Fifty healthy Sprague Dawley (SD) rats were randomized into the following 5 groups: sham, control, &al...
Source: Arquivos Brasileiros de Cardiologia - Category: Cardiology Source Type: research
A study by the University of Auckland found faeces transplanted from donors with a high level - and diversity - of 'good bacteria' in their guts are most likely to be successful.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Although admittedly small, a new study indicates that a combination of intermittent fasting together with some calorie restriction may give the best outcomes in terms of weight loss and overall health.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Diabetes & Endocrinology News Source Type: news
A U.S. FDA advisory panel to the voted 8-8 over whether to recommend approval of a treatment for type 1 diabetes developed by Sanofi and Lexicon Pharmaceuticals.
Source: PharmaManufacturing.com - Category: Pharmaceuticals Source Type: news
Almost everyone experiences bad breath once in a while. But for some people, bad breath is a daily problem, and they struggle to find a solution. Approximately 30% of the population complains of some sort of bad breath. Halitosis (Latin for “bad breath”) often occurs after a garlicky meal or in the morning after waking. Other causes of temporary halitosis include some beverages (including alcoholic drinks or coffee) and tobacco smoking. Some people may not be aware of their own halitosis and learn about it from a relative, friend, or coworker, causing some degree of discomfort and distress. In severe cases, bad...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Dental Health Source Type: blogs
Brooke C. Wilson, Tommi Vatanen, Wayne S. Cutfield, Justin M. O'Sullivan
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
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