Hsp27 expression and ratio between cell proliferation rate and apoptosis in breast cancer with and without axillary metastases

Conclusion: Quantitative analysis of Hsp27 demonstrated increased protein expression in primary neoplasm tissues and in lymph nodes in carcinomas without axillary sentinel lymph node metastasis. Although the methodology and the number of cases do not allow concluding that this behavior in metastatic disease is a constant finding, this justifies the need to evaluate this finding in future studies.RESUMO Introdu ção: O envolvimento do sistema imunológico no processo de neoplasias vem sendo cada vez mais estudado devido ao seu potencial em terapia antitumorais. Objetivos: Avaliar a expressão de heat shock protein 27 (Hsp27) em amostras teciduais de carcinomas ductais invasores com e sem presença de met ástase em linfonodo sentinela axilar, bem como estudar a relação da taxa de proliferação celular (Ki-76) e apoptose (caspase 3) em comparação com amostras de alteração fibrocística no tecido mamário. Métodos: Estudo transversal com amostras de tecidos coletados no Hospital São Lucas, e ntre setembro de 2001 e outubro de 2009, divididas em três grupos: 1. alteração fibrocística da mama (grupo-controle); 2. carcinoma ductal invasor de mama com presença de metástase linfonodal; e 3. sem presença de metástase linfonodal. Resultados: Observou-se expressão aumentada da Hsp27 n o grupo de carcinomas sem...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - Category: Pathology Source Type: research

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Conclusions: Whole-tumor radiomics on MR multiparametric images, DCE images changing over time points, and DWI images changing over different b-values provide a non-invasive analytical approach for breast cancer subtype classification and TN cancer identification.
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Conclusion: Several potential breast cancer-related genes and pathways were captured, including 7 novel upregulated genes and 76 novel downregulated genes that were not found in other studies. These genes are related to cell proliferation, movement and adhesion. They may be important for research into breast cancer mechanisms, particularly CST2 and CA4. A key signaling pathway, the ECM-receptor interaction signal pathway, was also identified as possibly involved in the development of breast cancer. PMID: 31182966 [PubMed - in process]
Source: Mol Biol Cell - Category: Molecular Biology Authors: Tags: Cell Mol Biol Lett Source Type: research
Publication date: Available online 12 June 2019Source: European Journal of RadiologyAuthor(s): Min Sun Bae, Blanca Bernard-Davila, Janice S. Sung, Elizabeth A. MorrisAbstractPurposeTo determine preoperative magnetic resonance imaging (MRI) features associated with positive or close margins in patients with breast cancer who underwent breast-conserving surgery (BCS).Materials and methodsA retrospective review identified 249 patients with invasive ductal carcinoma (IDC) who underwent preoperative MRI and BCS as a primary procedure between 2008 and 2010. The MR images were reviewed for descriptions of findings with no new int...
Source: European Journal of Radiology - Category: Radiology Source Type: research
We reported here that plakoglobin, as a key component in cell adhesion, can promote collective metastasis through facilitating IMPC clusters formation. In comparing the clinicopathological features of 451 IMPC patients and 282 IDC-NST patients, our results showed that tumor emboli were significantly higher in IMPC patients and were associated with a high frequency of metastasis. Both in vitro and in vivo data showed overexpression of plakoglobin in both the cell membrane and the cytoplasm of IMPC clusters. When plakoglobin was knocked down in IMPC cell models, the tumor cell clusters were depolymerized. Using mouse models,...
Source: Journal of Cancer - Category: Cancer & Oncology Authors: Tags: Research Paper Source Type: research
CONCLUSIONS: The frequency of 4-1BBL+ B cells significantly increased following a short time activation, and showed relative and significant associations with tumor grade and estrogen receptor status, respectively. More investigations are required to evaluate the potential of 4-1BBL+ B cells for use in immunotherapy. PMID: 31182685 [PubMed - in process]
Source: Iranian Journal of Immunology - Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research
CONCLUSIONS: MRI is the best predictor of tumor size in breast cancer. Histologic type and tumor size are key parameters when estimating tumor size and should be taken into account when planning surgery. Patient age does not interfere with the interpretation of imaging tests. PMID: 31186117 [PubMed - as supplied by publisher]
Source: Cirugia eEspanola - Category: Surgery Authors: Tags: Cir Esp Source Type: research
Purpose: Invasive lobular carcinomas (ILC) are characterised by loss of the cell adhesion molecule, E-cadherin, most commonly due to somatic CDH1 mutations. These are typically oestrogen receptor (ER)-positive/HER2-negative luminal tumours, which have a similar prognosis to that expected for luminal invasive ductal carcinomas (IDC). However, approximately 15% of ILC will be ER-negative; either at the time of breast cancer diagnosis or at metastatic relapse due to loss of ER expression. Previous studies have suggested that patients with triple-negative ILC have a superior prognosis to matched controls with triple-negative I...
Source: Clinical Oncology - Category: Radiology Authors: Source Type: research
Purpose: Invasive lobular carcinomas (ILC), characterised by loss of the cell adhesion molecule E-cadherin, are typically oestrogen receptor (ER)-positive/HER2-negative luminal tumours with a similar prognosis to that expected for luminal invasive ductal carcinomas (IDC). Less than 5% of classical ILC but up to 35% of pleomorphic ILC are HER2-positive. Previous studies have suggested similar benefit from trastuzumab for HER2-positive ILC and IDC, but data are limited [1].
Source: Clinical Oncology - Category: Radiology Authors: Source Type: research
Conclusion: The long-term complications of PAAG-injected breast augmentation are various and complex. Pathologically, these complications are associated with foreign body reaction, fibrosis, and inflammation.Breast Care
Source: Breast Care - Category: Cancer & Oncology Source Type: research
ConclusionSince accessory axillary breast tissue is out of the image of screening breast examination, it is necessary for the oncologists to be aware of this entity and associated pathologies. Their preventive excision in high risk women can also be considered.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
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