African-Americans may live longer after liver transplant if their donors are the same race

(American College of Surgeons) African-American adults undergoing liver transplant to treat liver cancer lived significantly longer if their organ donor was also African-American.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news

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Hepatocellular carcinoma (HCC) is the most common primary hepatic malignancy and the third most frequent cause of cancer-related deaths.[1,2] Although the prognosis of patients with advanced HCC remains poor, patients with early-stage HCC are eligible for curative treatments such as surgical resection, local ablation, and liver transplantation.[3,4] Therefore, accurate imaging diagnosis of early-stage HCC is important.
Source: Journal of Hepatology - Category: Gastroenterology Authors: Source Type: research
Conclusion: In conclusion, ERCP and MRCP-based indices have short-term prognostic value in PSC. However, more studies are required to validate their predictability of disease-related progression, such as liver decompensation, ascending cholangitis, cholangiocarcinoma and liver transplantation.
Source: The Saudi Journal of Gastroenterology - Category: Gastroenterology Authors: Source Type: research
In this study, a significant (30%) increase in maximum lifespan of mice was found after nonablative transplantation of 100 million nucleated bone marrow (BM) cells from young donors, initiated at the age that is equivalent to 75 years for humans. Moreover, rejuvenation was accompanied by a high degree of BM chimerism for the nonablative approach. Six months after the transplantation, 28% of recipients' BM cells were of donor origin. The relatively high chimerism efficiency that we found is most likely due to the advanced age of our recipients having a depleted BM pool. In addition to the higher incorporation rates, ...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Publication date: Available online 10 May 2019Source: European Journal of RadiologyAuthor(s): Donghui Guo, Dongsheng Gu, Honghai Wang, Jingwei Wei, Zhenglu Wang, Xiaohan Hao, Qian Ji, Shunqi Cao, Zhuolun Song, Jiabing Jiang, Zhongyang Shen, Jie Tian, Hong ZhengAbstractObjectivesTo assess whether radiomics signature can identify aggressive behavior and predict recurrence of hepatocellular carcinoma (HCC) after liver transplantation.MethodsOur study consisted of 133 patients with clinically confirmed HCC after liver transplantation from October 2011 to December 2016. Radiomics features were extracted from hepatic artery phas...
Source: European Journal of Radiology - Category: Radiology Source Type: research
Authors: Zhang R, Ou M, Zhang Y, Yan Q, Chen H, Lai L, Li Y, Xu F, Tang D, Sun X, Dong J, Dai Y, Sui W Abstract Liver cancer is the second leading cause of cancer mortality worldwide. Safer and more effective diagnostic methods for liver cancer are desirable, and biomarkers represent a potentially alternative method for diagnosis. The present study was designed to identify liver cancer biomarkers. We quantified the changes in serum protein levels between liver transplantation and healthy (control) females using isobaric tags for relative and absolute quantitation (iTRAQ) as well as proteomic analysis. A total of 13...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Authors: Yadav DK, Bai XL, Liang T Abstract Patients undergoing liver transplantation (LT) are at a high risk of dermatological complications compared to the general population as a result of long-term use of immunosuppressant. However, the risk is not as high as other solid organ transplantations (SOT), particularly for skin cancer. The liver is considered as an immune privileged organ since it has a low prevalence of humoral rejection in contrast to other SOT, and thus, LT requires a minimal amount of immunosuppressants compared to other SOT recipients. However, because of the large volume of the liver, patients ...
Source: Canadian Journal of Gastroenterology - Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research
By LYNLY JEANLOUIS Health insurance companies are standing in the way of many patients receiving affordable, quality healthcare. Insurance companies have been denying patient claims for medical care, all while increasing monthly premiums for most Americans. Many of the nation’s largest healthcare payers are private “for-profit” companies that are focused on generating profits through the healthcare system. Through a rigorous approval/denial system, health insurance companies can dictate the type care patients receive. In some cases, this has resulted in patients foregoing life-saving treatments or proc...
Source: The Health Care Blog - Category: Consumer Health News Authors: Tags: Health Policy Health insurance Lynly Jeanlouis private health insurance Quality improvement Quality of care Source Type: blogs
udy Abstract In solid organ transplant recipients (sOTRs), 5 years after transplantation cancer is a relevant cause of death. We aimed to report cancer incidence in the Swiss Transplant Cohort Study (STCS) between 2008 and 2014 and conducted a prospective cohort study of kidney, heart, lung, pancreas and liver transplant recipients enrolled into the STCS by retrospective analysis of collected data. The STCS provided data on 2758 solid organ transplants. In total, 134 cases of cancer were observed (30 liver, 21 prostate, 18 lung, 13 kidney, 52 other cancers). Standardised incidence ratios (SIRs) were highest for li...
Source: Swiss Medical Weekly - Category: General Medicine Authors: Tags: Swiss Med Wkly Source Type: research
ConclusionWe identified a group of Metallothionein genes as biomarkers to predict recurrence. The metallothionein genes were all down ‐regulated in tumor samples, suggesting that low metallothionein expression may be a promoter of tumor growth. In addition, using de novo assembly identified some unique biomarkers, further confirmed the necessity of conducting a de novo assembly in human cancer study.
Source: Molecular Genetics & Genomic Medicine - Category: Genetics & Stem Cells Authors: Tags: ORIGINAL ARTICLE Source Type: research
This study shows that mRNA levels of the aging related lamin A splice variant progerin, associated with premature aging in HGPS, were significantly upregulated in subjects with BMI ≥ 25 kg/m2. Moreover, our data revealed a significantly positive correlation of BMI with progerin mRNA. These data provide to our knowledge for the first-time evidence for a possible involvement of progerin in previously observed accelerated aging of overweight and obese individuals potentially limiting their longevity. Our results also showed that progerin mRNA was positively correlated with C-reactive protein (CRP). This might suggest an as...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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