New Ebola vaccine effective in trials with primates, ferrets

Scientists have developed a single dose treatment that has shown promise for combating the Ebola virus in tests with nonhuman primates and ferrets, a study says.
Source: Health News - - Category: Consumer Health News Source Type: news

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Publication date: Available online 15 February 2019Source: The LancetAuthor(s): Denis Malvy, Anita K McElroy, Hilde de Clerck, Stephan Günther, Johan van GriensvenSummaryEbolaviruses are pathogenic agents associated with a severe, potentially fatal, systemic disease in man and great apes. Four species of ebolaviruses have been identified in west or equatorial Africa. Once the more virulent forms enter the human population, transmission occurs primarily through contact with infected body fluids and can result in major epidemics in under-resourced settings. These viruses cause a disease characterised by systemic viral r...
Source: The Lancet - Category: General Medicine Source Type: research
(Natural News) The World Health Organization (WHO) recently included vaccine skeptics – people who are hesitant to vaccinate themselves or their children because they are concerned about the potential health risks – on their annual list of “global health threats,” along with serious dangers like superbugs, climate change, the Ebola virus, HIV and air pollution....
Source: - Category: Consumer Health News Source Type: news
Publication date: 12 February 2019Source: Cell Reports, Volume 26, Issue 7Author(s): Ian L. McWilliams, Jennifer L. Kielczewski, Derek D.C. Ireland, Jacob S. Sykes, Aaron P. Lewkowicz, Krishnamurthy Konduru, Biying C. Xu, Chi-Chao Chan, Rachel R. Caspi, Mohanraj Manangeeswaran, Daniela VerthelyiSummaryZaire Ebola virus (ZEBOV) survivors experience visual and CNS sequelae that suggests the ZEBOV glycoprotein can mediate neurotropism. Replication-competent rVSVΔG-ZEBOV-GP vaccine candidate is generally well tolerated; however, its potential neurotropism requires careful study. Here, we show that a single inoculation of...
Source: Cell Reports - Category: Cytology Source Type: research
[Deutsche Welle] Vaccination campaigns have started in the countries neighboring the DRC, while the Ebola virus continues to spread in the North-eastern regions.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
[Cameroon Tribune] The Health Ministry says a vaccination campaign saved more than 76,000 lives
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
[The Conversation Africa] Vaccines are recognised as one of the most powerful tools in controlling and preventing infectious diseases. This despite strong anti-vaccination movements around the globe.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
[The Conversation Africa] The World Health Organisation (WHO) has emphasised that an experimental vaccine is playing a major role in controlling the spread of Ebola in the ongoing outbreak in the Democratic Republic of Congo (DRC). Without the vaccine, the outbreak has the potential to spiral out of control, considering the country's social and political landscape as well as the sheer ability of the virus to spread.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
We examined hypothetical acceptability and perceptions of experimental Ebola vaccines among health care workers (HCWs), frontline workers, and the general public to guide ethical communication of risks and benefits of any experimental Ebola vaccine. METHODS: Between December 2014 and January 2015, we conducted in-depth interviews with public health leaders (N = 31), focus groups with HCWs and frontline workers (N = 20), and focus groups with members of the general public (N = 15) in Western Area Urban, Western Area Rural, Port Loko, Bombali, and Tonkolili districts. Themes were identified using qualitative...
Source: Vaccine - Category: Allergy & Immunology Authors: Tags: Vaccine Source Type: research
ConclusionAn Ebola pseudovirus detection system was successfully established and used to evaluate two Ebola vaccines. Both produced good immunogenicity. The findings lay the foundation for the development of new Ebola vaccines and screening for neutralizing monoclonal antibodies.
Source: Biomedical and Environmental Sciences - Category: Biomedical Science Source Type: research
The TWiVosophers review the Chinese plasma virome revealed by non-invasive prenatal testing, and a new filovirus genome from bats in China. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode ASV 2019 European Congress of Virology 2019 ASM Clinical Virology Symposium Intel ISEF judges needed Jerard Hurwitz age 90 RIP Paul has Measles now in French (virology blog) Chinese plasma virome (Cell) Blood virome of 8000 humans (TWiV 435) Měnglà filovirus f...
Source: This Week in Virology - MP3 Edition - Category: Virology Authors: Source Type: podcasts
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