Oral HRT for Menopause Has Highest VTE Risk, Dermal Route Safest Oral HRT for Menopause Has Highest VTE Risk, Dermal Route Safest

Women taking HRT for menopausal symptoms should be counseled to use transdermal preparations over oral ones to reduce their venous thromboembolism risk, conclude UK experts following large study.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Ob/Gyn & Women ' s Health News Source Type: news

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Abstract Supplementary estrogen plays important roles for female patients as convenient birth control, relief of postmenopausal symptoms, and in management of other selected problems. However, as is the case for essentially all medications, there are side effects. Short of a major pulmonary embolus, the most severe side effect of estrogen would appear to be sporadic, rare, and severe hypertriglyceridemia associated with acute pancreatitis. The occurrence of this fortunately rare problem usually happens in the presence of some preexisting and usually mild increase in triglycerides (TG). A case of chronic and severe...
Source: Current Vascular Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Curr Vasc Pharmacol Source Type: research
Thrombotic and bleeding risks, as well as the incidence and presentation of cardiovascular events and related outcomes, appear to differ between genders, partly in relation to variability in age, comorbidities and body size.Women experience frequent fluctuations of pro-thrombotic activity during their lifetime, related to menstrual cycles, the use of oral contraceptives, pregnancy, menopause, and hormone replacement therapy, all with potential impact on the clinical manifestations of atherosclerotic disease.
Source: International Journal of Cardiology - Category: Cardiology Authors: Tags: Review Source Type: research
JoAnn Manson reviews a large study that provides evidence about the safety of different estrogen formulations for menopausal hormone therapy.Medscape Ob/Gyn
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Ob/Gyn & Women ' s Health Commentary Source Type: news
Hormone replacement therapy has been shown to be effective in alleviating menopausal symptoms. However, its use is controversial owing to potential health risks, such as thromboembolism and cancer. Bioidentical hormone therapy has recently become popular as an alternative to conventional hormone replacement therapy. These bioidentical hormones have a molecular structure identical to endogenous hormones found in a woman's body. A claimed advantage of bioidentical hormone therapy is the compounding practice in order to individualize therapy depending on patient's own hormone levels and symptoms. However, there is no scientif...
Source: Dermatology Online Journal - Category: Dermatology Source Type: research
Conclusions: In postmenopausal Taiwanese women, HT may be associated with an increased risk of cardiovascular disease. Although the women in our population receiving HT were near menopausal age, their risk of cardiovascular disease was still higher than in the non-HT group.
Source: Menopause - Category: OBGYN Tags: Original Articles Source Type: research
Abstract Hormone replacement therapy has been shown to be effective in alleviating menopausal symptoms. However, its use is controversial owing to potential health risks, such as thromboembolism and cancer. Bioidentical hormone therapy has recently become popular as an alternative to conventional hormone replacement therapy. These bioidentical hormones have a molecular structure identical to endogenous hormones found in a woman's body. A claimed advantage of bioidentical hormone therapy is the compounding practice in order to individualize therapy depending on patient's own hormone levels and symptoms. However, th...
Source: Dermatol Online J - Category: Dermatology Authors: Tags: Dermatol Online J Source Type: research
Women taking HRT for menopausal symptoms should be counseled to use transdermal preparations over oral ones to reduce their venous thromboembolism risk, conclude UK experts following large study.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Ob/Gyn & Women ' s Health News Source Type: news
Semin Neurol 2018; 38: 627-633 DOI: 10.1055/s-0038-1673681Headache is a neurologic disorder that displays gender dichotomy. It is well established that there is a strong link between migraine headache and sex hormones, specifically estrogen, which influences the severity of migraines during the menstrual cycle, pregnancy, and menopause. Furthermore, the epidemiology of headaches during pregnancy and the postpartum period is very distinct from that in males or nonpregnant females, in part due to the hemodynamic and hematologic changes that occur during pregnancy. These changes put women at higher risk for cerebral venous th...
Source: Seminars in Neurology - Category: Neurology Authors: Tags: Review Article Source Type: research
Venous thrombosis is a well-known complication of sex hormone therapy, with onset typically within weeks to months after initiation. Worldwide, more than 100 million pre-menopausal women use combined oral contraceptives, thus tens to hundreds of thousands develop thrombosis annually, resulting in significant morbidity and mortality. Estrogens are thought to be the major thrombotic risk, although the impact of progestins is less clear. It has been hypothesized that progestin effects may be secondary to mitigation of the estrogen effect. Although it is known that estrogens and progestins can alter expression of coagulation f...
Source: Blood - Category: Hematology Authors: Tags: 331. Pathophysiology of Thrombosis: Risk Factors and Thromboembolism Source Type: research
Conclusions: This large population-based study suggests that participants receiving an estradiol transdermal system have a significantly lower incidence of venous thromboembolism than do participants receiving oral estrogen-only hormone therapy.
Source: Menopause - Category: OBGYN Tags: Commemorative Papers Source Type: research
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