Efficient synthesis of chiral β-hydroxy sulfones via iridium-catalyzed hydrogenation

Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C8OB02923G, CommunicationLin Tao, Congcong Yin, Xiu-Qin Dong, Xumu Zhang A highly efficient Ir-catalyzed asymmetric hydrogenation of prochiral β-keto sulfones was successfully developed, affording a series of chiral β-hydroxy sulfones with excellent results (up to>99% conversion, 99% yield,>99% ee, and 20  000 TON). To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry

Source: RSC - Organic and Biomolecular Chemistry - January 10, 2019 Category: Molecular Biology Authors: Lin Tao Source Type: research