A comprehensive study of immunology repertoires in both preoperative stage and postoperative stage in patients with colorectal cancer

ConclusionIn conclusion, CRC patients were presented with different immune repertoire in comparison with healthy controls. In this study, significant difference in TRBV and TRBJ gene usage in between case and control group could provide some potential biomarker for the diagnosis and the treatment of the patients with CRC.
Source: Molecular Genetics & Genomic Medicine - Category: Genetics & Stem Cells Authors: Tags: ORIGINAL ARTICLE Source Type: research

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Conclusion The clinical and pathological features exhibit differences between synchronous CRC and solitary CRC and the prognosis of patients with synchronous CRC was poorer than those with solitary CRC.
Source: European Journal of Gastroenterology and Hepatology - Category: Gastroenterology Tags: Original Articles: Gastroenterology Source Type: research
This study compares the severity of postoperative complications in patients undergoing LRS who have received lidocaine intraoperatively either intravenously or via paravertebral administration versus saline.Methods/designWe will conduct a single-center randomized controlled trial involving 153 patients undergoing LRS through a thoracoscopic approach. The patients will be randomly assigned to one of the following study groups: intravenous lidocaine with more paravertebral thoracic (PVT) saline, PVT lidocaine with more intravenous saline, or intravenous remifentanil with more PVT saline. The primary outcome will be the compa...
Source: Trials - Category: Research Source Type: clinical trials
This study was to explore the impact of ropivacaine on the adhesion of tumour cells, providing evidences of its influence on the prognosis of carcinoma.Materials and methodsHuman umbilical vein endothelial cells (HUVECs) were pre-treated with ropivacaine (10–7–10–5 M; 30 min) prior to treatment with tumour necrosis factor alpha (TNF α) (10 ng ml−1; 1, 4 and 8 h). Intercellular adhesion molecule-1 (ICAM-1), endothelial-selectin (CD62E) and vascular cell adhesion molecule-1 (VCAM-1) mRNA levels were detected via quantitative reverse-transcriptase polymerase chain reaction (qRT-PCR). To clar...
Source: Journal of Anesthesia - Category: Anesthesiology Source Type: research
Conclusion– This survey indicated that perioperative steroid use is currently widespread. Sufficient equipoise exists for a trial in this area with regard to examining the impact of dexamethasone on postoperative complications and the postoperative systemic inflammatory response. Respondents favoured a 3-armed trial – no steroids vs low-dose steroids vs high-dose steroids.
Source: Annals of Medicine and Surgery - Category: General Medicine Source Type: research
CONCLUSIONS: Adequate and improved pain control in patients with cancer, even in advanced stages, with concurrent quality of life maintenance is attainable. Results from this large-scale, multicenter, single-group cohort supplement existing RCT data that support IDDS as a safe and effective therapeutic option with a positive benefit-risk ratio in the treatment of cancer pain. PMID: 31567325 [PubMed - as supplied by publisher]
Source: Anesthesia and Analgesia - Category: Anesthesiology Authors: Tags: Anesth Analg Source Type: research
Authors: Siekmann W, Tina E, Von Sydow AK, Gupta A Abstract Regional anesthesia may prolong survival following surgery for different types of cancers. The mechanisms behind this are unclear but direct effects on cancer cells by local anesthetics (LA) have been suggested. The aim of this study was to investigate if lidocaine or ropivacaine have a dose-dependent effect on the cell viability and proliferation of a primary and a secondary colon carcinoma cell line in vitro. The colon cancer cell lines SW480 derived from primary tumor and SW620 from a metastatic site in the same patient were exposed to increasing concen...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
AbstractBackgroundColorectal cancer remains a common cause of cancer death in the UK, with surgery  being the mainstay of treatment. An objective measurement of the suitability of each patient for surgery, and their risk–benefit calculation, would be of great utility. We postulate that sarcopenia (low muscle mass) could fulfil this role as a prognostic indicator. The aim of this study was to d etermine the relationship between sarcopenia and long-term outcomes in patients undergoing elective bowel resection for colorectal cancer.MethodsOne hundred and sixty-three consecutive patients who had elective curative co...
Source: Techniques in Coloproctology - Category: Surgery Source Type: research
Conditions:   Cancer, Breast;   Cancer Colorectal;   Cancer Prostate;   Cancer, Lung;   Cancer Melanoma Skin;   Cancer, Other Interventions:   Drug: Propofol;   Drug: isoflurane, sevoflurane or desflurane Sponsors:   Peter MacCallum Cancer Centre, Australia;   M.D. Anderson Cancer Center;   Melbourne Health;   The Alfred Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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