Alzheimer's biomarkers could affect races differently

Using MRI and PET scans and cerebrospinal fluid assays, researchers have collected...Read more on AuntMinnie.comRelated Reading: MRI offers possible link between microbleeds, Alzheimer's Brain MRI offers new insight into blood deposits New Alzheimer's definition relies on imaging biomarkers MRI technique locates areas of cognitive impairment MRI links brain leaks to Alzheimer's disease
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news

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This study shows that the flowers and fruit of Z. absinthifolia can be a new potential resource of natural antioxidant and anticholinesterase compounds.
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
AbstractThe recent studies in Morphometric Magnetic Resonance Imaging (MRI) have investigated the abnormalities in the brain volume that have been associated diagnosing of the Alzheimer ’s Disease (AD) by making use of the Voxel-Based Morphometry (VBM). The system permits the evaluation of the volumes of grey matter in subjects such as the AD or the conditions related to it and are compared in an automated manner with the healthy controls in the entire brain. The article also rev iews the findings of the VBM that are related to various stages of the AD and also its prodrome known as the Mild Cognitive Impairment (MCI...
Source: Journal of Medical Systems - Category: Information Technology Source Type: research
This study tested the efficacy of the phosphodiesterase type III inhibitor cilostazol in Alzheimer ’s disease patients with white matter lesions treated with donepezil in comparison with donepezil monotherapy using fluorodeoxyglucose (18F) positron-emission tomography (FDG PET). A 24-week, randomized, double-blind, placebo-controlled, parallel-group study was conducted. Thirty-six Alzheimer ’s disease patients with white matter lesions who received donepezil (n = 18 each in the cilostazol and placebo groups) were enrolled. Participants underwent pre and post FDG PET imaging scans and three rounds ...
Source: Neurotherapeutics - Category: Neurology Source Type: research
CONCLUSIONS: Hippocampal atrophy progresses asymmetrically with age in cognitively healthy subjects. Hippocampal parenchymal fraction asymmetry is significantly higher in men than women and in mild cognitive impairment/Alzheimer disease relative to cognitively healthy individuals.
Source: American Journal of Neuroradiology - Category: Radiology Authors: Tags: ADULT BRAIN Source Type: research
Publication date: Available online 11 February 2019Source: Revista Española de Medicina Nuclear e Imagen Molecular (English Edition)Author(s): Hyun-Jung No, Hyon-Ah Yi, Kyoung Sook Won, Hyuk Won Chang, Hae Won KimAbstractAimWhite matter lesions (WMLs), detected as hyperintensities in T2-weighted MRI, represent small vessel disease in the brain and are considered a potential risk factor for memory and cognitive impairment. It has not been sufficiently evidenced that cognitive impairment in patients with Alzheimer's disease is caused by WMLs as well as β-amyloid (Aβ) pathology. The aim of this study was to e...
Source: Revista Espanola de Medicina Nuclear e Imagen Molecular - Category: Nuclear Medicine Source Type: research
Abstract Alzheimer's disease (AD) remains a significant burden on society. In the search for new AD drugs, modulators of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) are of particular interest as loss of synaptic AMPARs has been linked to AD learning and memory deficits. Previously reported fluorine-containing BPAM121, an AMPA positive allosteric modulator (pam) with high activity, low toxicity and slow metabolism, was considered to be a perfect 18F-labelled candidate for positron emission tomography (PET) AD diagnostic investigations. For the preclinical use of this compound, an a...
Source: ChemMedChem - Category: Chemistry Authors: Tags: ChemMedChem Source Type: research
We describe a novel method based on the anisotropic heat equation that explicitly accounts for the presence of partial tissue volumes to more accurately estimate cortical thickness. The anisotropic term uses gray matter fractions to incorporate partial tissue voxels into the thickness calculation, as demonstrated through simulations and experiments. We also show that the proposed method is robust to the effects of finite voxel resolution and blurring. In comparison to methods based on hard intensity thresholds, the heat equation based method yields results with in-vivo data that are more consistent with histological findin...
Source: MICCAI International Conference on Medical Image Computing and Computer-Assisted Intervention - Category: Radiology Tags: Med Image Comput Comput Assist Interv Source Type: research
This study aimed to examine short-term reliability of the default-mode network (DMN), one of the main haemodynamic patterns of the brain.Materials and methodsUsing a 1.5 T Philips Achieva scanner, two consecutive resting-state fMRI runs were acquired on 69 healthy adults, 62 patients with mild cognitive impairment (MCI) due to AD, and 28 patients with AD dementia. The anterior and posterior DMN and, as control, the visual-processing network (VPN) were computed using two different methodologies: connectivity of predetermined seeds (theory-driven) and dual regression (data-driven). Divergence and convergence in network stren...
Source: Magnetic Resonance Materials in Physics, Biology and Medicine - Category: Materials Science Source Type: research
Conclusion: 11C-LSN3172176 exhibits excellent in vivo binding and imaging characteristics in non-human primates and appears to be the first appropriate radiotracer for PET imaging of human M1 AChR. PMID: 30733324 [PubMed - as supplied by publisher]
Source: Methods of Information in Medicine - Category: Information Technology Authors: Tags: J Nucl Med Source Type: research
This study aimed to examine short-term reliability of the default-mode network (DMN), one of the main haemodynamic patterns of the brain. MATERIALS AND METHODS: Using a 1.5 T Philips Achieva scanner, two consecutive resting-state fMRI runs were acquired on 69 healthy adults, 62 patients with mild cognitive impairment (MCI) due to AD, and 28 patients with AD dementia. The anterior and posterior DMN and, as control, the visual-processing network (VPN) were computed using two different methodologies: connectivity of predetermined seeds (theory-driven) and dual regression (data-driven). Divergence and convergence in netwo...
Source: Magma - Category: Radiology Authors: Tags: MAGMA Source Type: research
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