Role of cenicriviroc in the management of nonalcoholic fatty liver disease.

Role of cenicriviroc in the management of nonalcoholic fatty liver disease.
World J Gastroenterol. 2018 Dec 28;24(48):5415-5417
Authors: Neokosmidis G, Tziomalos K
Abstract
Nonalcoholic fatty liver disease (NAFLD) is the commonest chronic liver disease in high-income countries and is associated with increased morbidity and mortality. Macrophages appear to play an important role in the development and progression of hepatic fibrosis in patients with NAFLD. Accordingly, modulation of macrophage trafficking might represent an attractive therapeutic strategy in this population. Cenicriviroc is an oral inhibitor of the chemokine ligand 2/C-C chemokine receptor 2 pathway, which plays an important role in the hepatic recruitment of the macrophages. Preclinical studies and a phase 2b study in humans suggest that this agent might hold promise in the management of NAFLD.
PMID: 30622370 [PubMed - in process]

Source: World Journal of Gastroenterology - December 28, 2018 Category: Gastroenterology Authors: Neokosmidis G, Tziomalos K Tags: World J Gastroenterol Source Type: research