New Data Boosts Value Proposition of AlloSure

When our kidneys fail to function as they should, our treatment options generally begin with dialysis and end with a kidney transplant. Unfortunately, transplanted kidneys last, on average, between 12 years and 15 years (depending on if the donor is living or deceased, and if they are a relative or not). Some recipients are lucky if they even get five good years out of their transplanted kidney. CareDx has already established the clinical value of AlloSure, a donor-derived cell-free DNA test designed to assess allograft health in kidney transplant patients, and new data demonstrates the test's clinical utility in patients who require repeat kidney transplants. The findings, published in the American Journal of Transplantation in December, could go a long way toward filling an unmet need in the space by helping doctors closely monitor and optimize care for this particular population. "The relevance of this paper is we've demonstrated for the first time how [the test] actually performs in these patients who have a second or even third or fourth transplant," CareDx Chief Medical Officer Jim Yee told MD+DI. Yee explained that most of the time when a patient receives a new kidney, their failed kidney is left in the body. He said 15% of transplant patients have more than one transplanted kidney in their body. Brisbane, CA-based CareDx initiated the study to find out how its AlloSure test performs for those patients.Â&n...
Source: MDDI - Category: Medical Devices Authors: Tags: IVD Source Type: news

Related Links:

Conclusions. DWF and DC-GF in kidney transplant recipients represent differing clinical phenotypes occurring in distinct patient populations. Reducing the impact of DWF requires better definition of causes and clinical course and then trials of therapies to improve outcomes. Composite endpoints in clinical trials that group DWF and DC-GF together may obscure important clinical findings.
Source: Transplantation - Category: Transplant Surgery Tags: Original Clinical Science—General Source Type: research
We present a combined kidney-pancreas transplant patient who developed SAGN due to Staphylococcus aureus bacteremia from an old infected arteriovenous (AV) graft, which occurred after a long period of stable allograft function. Clinical improvement occurred following surgical debridement and appropriate antibiotics with subsequent clearance of bacteremia. However, 3 weeks later he presented with severe acute kidney injury related to rapidly progressive glomerulonephritis. Renal allograft biopsy revealed immune complex glomerulonephritis with predominance of IgA and C3 in subendothelial and mesangial deposits, consistent wi...
Source: Clinical Nephrology - Category: Urology & Nephrology Authors: Tags: Clin Nephrol Source Type: research
We report a case series of six kidney and pancreas transplant recipients who presented in an unusually short time frame during the COVID-19 pandemic with transplant organ dysfunction and rejection (Table 1). Mean time from the time of transplant to the current presentation was 7.3 ± 4 years. Of these six patients, three had severe allograft dysfunction requiring initiation of dialysis or insulin therapy.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: letters to the editor Source Type: research
In this study, we prospectively evaluated RI changes after AVF ligation in kidney transplanted patients. METHODS: We enrolled 22 stable transplanted patients. Mean RI was measured before AVF ligation (T0), 18 to 24 h (T1) and 6 months (T6) after surgery; mean blood pressure (mBP), heart rate (HR), serum creatinine (sCr), estimated glomerular filtration rate (eGFR), 24 h proteinuria (24 h-P), immunosuppressive drug blood levels (IS) and antihypertensive drugs were also recorded. RESULTS: AVF ligation was performed 3.1 years (IQR: 2.1-3.8) after transplantation. Median AVF flow (Qa) was 1868 mL/min (IQR: 1538-2712) a...
Source: The Journal of Vascular Access - Category: Surgery Tags: J Vasc Access Source Type: research
The direct association of obesity with overall health is incontrovertible, including an association with increased cardiovascular disease and higher mortality rates. The health outcomes of obesity are further exacerbated in patients with end-stage kidney disease (ESKD), and compounding this problem, the one intervention that can dramatically improve life span, kidney transplant, is often not offered to these patients. Lassalle et al showed that patients with a body mass index (calculated as weight in kilograms divided by height in meters squared) of 31 or more were less likely to receive a kidney transplant, and inversely,...
Source: JAMA Surgery - Category: Sports Medicine Source Type: research
Conclusions. Our prediction model is the first based on an Asian population, can be used immediately after transplantation. The model can be accessed at
Source: Transplantation - Category: Transplant Surgery Tags: Original Clinical Science—General Source Type: research
CONCLUSION: Blood transfusion under strong immunosuppressive cover within a one-week post-operative period is safe with no significant association with the development of de novo HLA-DSA, HLA-Ab or clinical rejection. PMID: 32327243 [PubMed - as supplied by publisher]
Source: Human Immunology - Category: Allergy & Immunology Authors: Tags: Hum Immunol Source Type: research
Although lung transplantation outcomes in the short term have improved in the past decade, the median survival has stagnated at 6-7 years.[1] Chronic lung allograft dysfunction, infection, malignancy and other medical complications are the predominant causes of graft failure and death beyond the first few years after lung transplantation.[1, 2] Among medical complications, renal dysfunction is a major factor contributing to both early and late morbidity and mortality.[3] Acute kidney injury (AKI) has been reported in up to two-thirds of patients in the perioperative period with 5-8% requiring dialysis in the first few mont...
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: Editorial Source Type: research
Authors: Elec FI, Moisoiu T, Socaciu MA, Elec AD, Muntean AM, Iacob G, Badea RI Abstract A 62-year-old woman who underwent kidney transplantation in 2014 was diagnosed with HIV infection in 2018. Grey scale and Doppler ultrasound evaluation revealed a normal aspect of the allograft. Contrast-enhanced ultrasound detected a quick cortical contrast uptake followed by a rapid cortical wash-out. This behavior was interpreted as a sign of inflammation. Ten months after ultrasound evaluation the graft presented severe disfunction and the patient was reintroduced into the hemodialysis program. PMID: 32190861 [PubMed - ...
Source: Medical Ultrasonography - Category: Radiology Tags: Med Ultrason Source Type: research
Conclusion: CAM practice and herb consumption were highly prevalent among patients with CKD. Patients inadequately inform the primary physicians about their CAM practices. Therefore, healthcare providers are encouraged to inquire about these practices. PMID: 32099440 [PubMed]
Source: International Journal of Nephrology and Renovascular Disease - Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research
More News: Bone Graft | Dialysis | Kidney Transplant | Kidney Transplantation | Medical Devices | Medicare | Study | Transplant Surgery | Transplants | Urology & Nephrology