Pregnancy in Acromegaly is safe and is associated with improvements in GH/IGF-1 concentrations.

We present a case series of 17 pregnancies in 12 women with acromegaly. 12 women with acromegaly who completed pregnancy were identified from centres involved in the Irish Pituitary Study. 11 women had pituitary macroadenomas, one woman had a microadenoma. Only 5/17 pregnancies had optimal biochemical control of acromegaly pre-conception, as defined by IGF-1 concentration in the age related reference level and plasma GH concentration of
Source: European Journal of Endocrinology - Category: Endocrinology Authors: Tags: Eur J Endocrinol Source Type: research

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Role of the thioredoxin interacting protein in diabetic nephropathy and the mechanism of regulating NOD‑like receptor protein 3 inflammatory corpuscle. Int J Mol Med. 2019 Jun;43(6):2440-2450 Authors: Gu C, Liu S, Wang H, Dou H Abstract Inflammatory response serves an important role in diabetic nephropathy (DN); however, the mechanism of inflammatory response results in renal damage is not yet clear. The aim of the present study was to investigate the role of the thioredoxin interacting protein (TXNIP)/NOD‑like receptor protein 3 (NLRP3) axis‑mediated activation of NLRP3 inflammasome in DN. A di...
Source: International Journal of Molecular Medicine - Category: Molecular Biology Authors: Tags: Int J Mol Med Source Type: research
Conclusion: Preoperative levels of serum leptin were higher in C-section patients with labor pain than in those without labor pain, and increased serum leptin levels were associated with decreased preoperative pain t hreshold and increased postoperative analgesic consumption in our study population. Postoperative analgesic requirements may vary among patients, and their requirements might be predicted using preoperative indicators. Serum levels of leptin might be one such indicator and this warrants further stud ies with larger sample sizes.
Source: Medical Principles and Practice - Category: Internal Medicine Source Type: research
This study aimed to describe the first-year falls incidence, circumstances and consequences among persons discharged home after stroke in Ireland, and to examine the association between potential r...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Falls Source Type: news
Abstract T1R3 protein, the main subunit of the sweet taste receptor and receptor of amino acid taste, is expressed in the epithelium of the tongue and gastrointestinal tract, in β cells of the pancreas, hypothalamus, and numerous other organs. Recently, convincing evidences on the involvement of T1R3 in the control of carbohydrate and lipid metabolism, and the control of incretin and insulin production were obtained. In the study on Tas1r3-gene knockout mouse strain and parent C57BL/6J strain as a control, the data on the effect of T1R3 on morphological characteristics of Langerhans islets in the pancreas wer...
Source: Doklady Biological Sciences - Category: Biology Authors: Tags: Dokl Biol Sci Source Type: research
WAMC: cGPA/sGPA/nsGPA: 3.64/3.52/3.93 MCAT: Taking the real deal on 05/23 AAMC FL1: 513 (127/130/127/129) AAMC FL2: AAMC FL3: 515 (129/128/130/128) State of Residence: OR (Strong ties to NY and VT) Race/Ethnicity: White, non-Hispanic UG Institute: Ordinary state school Clinical experience: by matriculation -- 1200+ hours as a scribe for a surgeon ~300 hours volunteering at a diabetes clinic (moderate amount of patient... WAMC + School List (3.64, 515)
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: What Are My Chances? WAMC Medical Source Type: forums
Download the flyer UCLA statement on measles case1. What is measles?Measles is a highly contagious disease that is caused by a virus that lives in the nose and throat. The symptoms of measles include:Fever   (101°F or higher)CoughRunny noseRed watery eyesRash of red spots. Some are slightly raised. Typically starts on the face or hairline and spreads to the rest of the body.Measles can lead to serious illnesses, hospitalization, and even death. Serious illnesses include:DiarrheaEar InfectionBrain Damage        Pregnant women, infants, young children, and persons with a weakened i...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
Source: Primary Care Diabetes - Category: Primary Care Source Type: research
Source: Primary Care Diabetes - Category: Primary Care Source Type: research
Conclusion: The findings of this review support the evidence that sweet cherries can be applied in pharmaceutical and food formulations, since they are able to diminish free radical species and proinflammatory markers, preventing and/ or ameliorating oxidative-stress disorders.
Source: Current Nutrition and Food Science - Category: Nutrition Source Type: research
The very large economic and social burdens of fracture-related complications make rapid fracture healing a major public health goal. The role of parathyroid hormone (PTH) in treating osteoporosis is generally accepted, but the effect of PTH on fracture healing is controversial. This meta-analysis was designed to investigate the efficacy and safety of PTH in fracture healing. The EMBASE, PubMed, and Cochrane Library databases were systematically searched from the inception dates to April 26, 2018. The primary randomized clinical trials comparing PTH treatment for fracture healing with placebo or no treatment were identified...
Source: Clinics - Category: General Medicine Source Type: research
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