Interrater agreement in the diagnosis of chronic lung allograft dysfunction after lung transplantation

Chronic lung allograft dysfunction (CLAD) affects>50% of lung transplant recipients (LTRs) by 5 years and remains the primary reason for graft failure.1 It has been increasingly recognized that CLAD is a heterogeneous diagnosis with a variable prognosis and different phenotypes: bronchiolitis obliterans syndrome (BOS) and restrictive allograft syndrome (RAS). Precise diagnosis of CLAD remains difficult as there are no clinically validated biomarkers, and diagnosis can be subjective, hinging on the correct interpretation of pulmonary function tests (PFTs) coupled with exclusion of clinical confounders.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: RESEARCH CORRESPONDENCE Source Type: research