A comparative analysis of overall survival between high-dose-rate and low-dose-rate brachytherapy boosts for unfavorable-risk prostate cancer

External beam radiation therapy (EBRT) with low-dose-rate (LDR) brachytherapy boost has been associated with improved biochemical progression –free survival and overall survival (OS) compared with dose-escalated EBRT (DE-EBRT) alone for unfavorable-risk prostate cancer. However, it is not known whether high-dose-rate (HDR) boost provides a similar benefit. We compare HDR boost against LDR boost and DE-EBRT with respect to OS.
Source: Brachytherapy - Category: Cancer & Oncology Authors: Source Type: research

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ConclusionssRP was safe, feasible, and effective using either an open or robot-assisted approach, in experienced hands. Age, preoperative clinical stage, NS procedure, and pathological GS were linked with BCR after sRP.
Source: World Journal of Urology - Category: Urology & Nephrology Source Type: research
Condition:   Prostate Cancer Intervention:   Radiation: LDR Brachytherapy and External Beam Radiation Therapy Sponsor:   British Columbia Cancer Agency Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
ConclusionS-HIFU and S-RP could both be considered valuable LST options for patients with radiation-recurrent nonmetastatic PCa with sufficient life expectancy. S-RP is associated with more pad-dependent patients at 12  months.
Source: World Journal of Urology - Category: Urology & Nephrology Source Type: research
Publication date: Available online 19 January 2019Source: European UrologyAuthor(s): Alexander P. Cole, Quoc-Dien Trinh
Source: European Urology - Category: Urology & Nephrology Source Type: research
Publication date: Available online 19 January 2019Source: European UrologyAuthor(s): Amar U. Kishan, William A. Hall, Daniel E. Spratt
Source: European Urology - Category: Urology & Nephrology Source Type: research
ConclusionsThere has been progress in the delivery of radiotherapy, enabling the administration of higher doses with minimal tradeoff in terms of slightly increased or equal toxicity. There is a need to focus future improvements in radiotherapy on sparing critical structures to reduce GU and GI morbidities. While complications such as fistulae, bone toxicity, and secondary malignancy are rare, there is a need for higher-quality studies assessing these outcomes and their management.Patient summaryIn this report, we review the literature regarding pelvic complications following modern primary prostate cancer radiotherapy and...
Source: European Urology - Category: Urology & Nephrology Source Type: research
Conclusions: To our knowledge, this is the first report to compare the GU and gastrointestinal toxicities between the combination therapy and BT monotherapy (160 Gy) for localized prostate cancer. Unexpectedly, there were more late GU toxicities (except for hematuria) in the BT monotherapy group. PMID: 30479615 [PubMed]
Source: Journal of Contemporary Brachytherapy - Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research
Publication date: Available online 10 November 2018Source: European UrologyAuthor(s): Sebastian Berg, Alexander P. Cole, Marieke J. Krimphove, Junaid Nabi, Maya Marchese, Stuart R. Lipsitz, Joachim Noldus, Toni K. Choueiri, Adam S. Kibel, Quoc-Dien TrinhAbstractA previous study comparing external beam radiation therapy with/without brachytherapy (EBRT ± BT) and radical prostatectomy (RP) for high-risk localized prostate cancer (PCa) did not find a difference in overall survival (OS) between the treatments. However, this study was limited by short follow-up and assessment of OS in patients of divergent age ...
Source: European Urology - Category: Urology & Nephrology Source Type: research
This is a retrospective study conducted to report the tumor control and late toxicity outcomes of patients with intermediate-risk prostate cancer undergoing combination external beam radiation therapy and low dose rate brachytherapy (LDR-PB).
Source: Journal of Medical Imaging and Radiation Sciences - Category: Radiology Authors: Tags: Research Article Source Type: research
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