CaMKII signaling in heart diseases: Emerging role in diabetic cardiomyopathy
Calcium/calmodulin-dependent protein kinase II (CaMKII) is upregulated in diabetes and significantly contributes to cardiac remodeling with increased risk of cardiac arrhythmias. Diabetes is frequently associated with atrial fibrillation, coronary artery disease, and heart failure, which may further enhance CaMKII. Activation of CaMKII occurs downstream of neurohormonal stimulation (e.g. via G-protein coupled receptors) and involve various posttranslational modifications including autophosphorylation, oxidation, S-nitrosylation and O-GlcNAcylation.
CONCLUSION: Patients with thyroid disease were found to have a higher risk for uveitis. For certain age groups or patients without diabetes or hypertension, the role of thyroid disease might be more crucial for uveitis development. PMID: 32643974 [PubMed - as supplied by publisher]
Carbon monoxide (CO) poisoning has been associated with direct toxicity to the cardiovascular system by causing arrhythmias through prolongation of QTc. It has been reported to have arrhythmogenic potential likely due to its action on the cardiac membranes...
Authors: Okosun IS, Nkemjika S, Okosun B, Lyn R, Airhihenbuwa CO Abstract AIM: To determine differences in lifestyle modification practices and use of prescription drugs in a representative sample of Mexican American (MA), non-Hispanic White (NHW), and non-Hispanic Black (NHB) elderly Americans with metabolic syndrome (MetS). METHODS: Data from the United States National Health and Nutritional Examination Surveys were used in this study. Lifestyle modification practices include ongoing physical activity, weight control, and ongoing diet modifications. Prescription drugs include anti-diabetic, anti-obesity, lipi...
Publication date: 11–17 July 2020Source: The Lancet, Volume 396, Issue 10244Author(s): Deepak L Bhatt, Philippe Gabriel Steg
Publication date: 11–17 July 2020Source: The Lancet, Volume 396, Issue 10244Author(s): Gerald Chi, Jolanta Marszalek
CONCLUSIONS: Thawing rate was a novel predictor of acute PVI and the ITR15 was the most valuable predictor of acute PVI. In addition, ITR15 was a predictive factor ensuring long-term PVI (vagus reflex). Our study showed that thawing rate may serve in th e early identification of useless cryoballoon ablation.
Publication date: Available online 9 July 2020Source: The Lancet Diabetes &EndocrinologyAuthor(s): S Le Brocq, K Clare, M Bryant, K Roberts, AA Tahrani, writing group form Obesity UK, Obesity Empowerment Network, UK Association for the Study of Obesity
Publication date: Available online 10 July 2020Source: Best Practice &Research Clinical Endocrinology &MetabolismAuthor(s): Joseph G. Verbalis
Publication date: September 2020Source: Biomedicine &Pharmacotherapy, Volume 129Author(s): Fang Yang, Qingsong Qu, Chongyan Zhao, Xing Liu, Pengshuo Yang, Zhixun Li, Lu Han, Xinyuan Shi
Publication date: September 2020Source: Biomedicine &Pharmacotherapy, Volume 129Author(s): Lindokuhle Patience Mabuza, Mlindeli Wilkinson Gamede, Sanam Maikoo, Irvin Noel Booysen, Phikelelani Siphosethu Ngubane, Andile Khathi