Mice sleeping fitfully provide clues to insomnia
(Washington University School of Medicine) Researchers at Washington University School of Medicine in St. Louis -- working with mice with sleep problems similar to those experienced by people with the genetic disease neurofibromatosis type 1 (NF1) -- believe the animals will help shed light on insomnia linked to NF1 or other factors.
Title says it all. #1.) "My widget is broken". - This is generally a PEG tube that is broken, or a line that won't flush, or a whatever. In nearly every circumstance, this can either WAIT UNTIL MORNING and/or CAN BE TAKEN CARE OF IN A THOUSAND OTHER SETTINGS THAN THE ER. 3:30 AM PEG tube dysfunction?! Put the patient back to bed, and then call the facility MD at 7 AM. 10:30 PM catheter that won't drain urine? Flush it, and let the old man sleep. He'll sleep hard overnight. Then, sort... Two Chief Complaints that drive me nuts.
ConclusionsMultiple physiological and contextual factors appear to contribute to player performance in international rugby competition. Measurement of these factors may guide training and management practices, a potential practical consequence but also advancing understanding from marker to causal link.
Walter T. McNicholas
TEOFILO LEE-CHIONG Jr, MD
Sleep and Performance
SLEEP MEDICINE CLINICS
This article reports on sleepiness, drowsiness, tiredness, and fatigue. An assessment of sleepiness can be done with electroencephalograms, electrooculograms, and electromyograms in validated tests, such as the multiple sleep latency test and the maintenance of wakefulness test. These 2 tests serve as references for quantitative assessment of daytime sleepiness and drowsiness. Correlates for sleepiness, such as reaction time tests, can be used but are less reliable. Questionnaires are self-administered and popular measures for perceived sleepiness. Driver drowsiness assessment is an important part of sleep laboratory testi...
Publication date: Available online 18 October 2019Source: European UrologyAuthor(s): Christopher R. Chapple, Francisco Cruz, Linda Cardozo, David Staskin, Sender Herschorn, Nurul Choudhury, Matthias Stoelzel, John Heesakkers, Emad SiddiquiAbstractBackgroundMirabegron, a β3-adrenoreceptor agonist, is an alternative drug to antimuscarinics for overactive bladder (OAB) symptoms.ObjectiveTo summarise safety and efficacy reporting of mirabegron treatment for OAB symptoms.Design, setting, and participantsPooled data analysed from 10 phase 2–4, double-blind, 12-wk mirabegron monotherapy studies in adults with OAB who h...
AbstractPurposeTo evaluate the efficacy and safety of desmopressin treatment in women with nocturia.MethodsThe PubMed, EMBASE, ISI web of knowledge, and the Cochrane Controlled Trial Register of Controlled Trials were searched from their inception date till April, 2019. The meta-analysis was performed by Revman 5.3. This review also stratified each outcome by dose ( 25 μg) to explore the differences in the dose response for orally disintegrating tablet (ODT).ResultsSeven publications with seven trials were included in this review. The methodological quality of these trials was fair, and four studies had low...