Evolution of daptomycin resistance in coagulase negative staphylococci involves mutations of the essential two component regulator WalKR.

This study highlights the significance of CoNS in evolving daptomycin resistance and showed that walKR is shared among the staphylococcal species as being involved in antibiotic resistance development. Notably, we did not observe mutations in genes responsible for phospholipid biosynthesis or an altered cell surface charge, suggesting that reduced daptomycin susceptibility in CoNS may emerge in a fashion distinct from S. aureus.
PMID: 30617095 [PubMed - as supplied by publisher]

Source: Antimicrobial Agents and Chemotherapy - January 7, 2019 Category: Microbiology Authors: Jiang JH, Dexter C, Cameron DR, Monk IR, Baines S, Abbott IJ, Spelman DW, Kostoulias X, Nethercott C, Howden BP, Peleg AY Tags: Antimicrob Agents Chemother Source Type: research