Mini EXPLORER II: a prototype high-sensitivity PET/CT scanner for companion animal whole body and human brain scanning.

Mini EXPLORER II: a prototype high-sensitivity PET/CT scanner for companion animal whole body and human brain scanning. Phys Med Biol. 2019 Jan 08;: Authors: Lyu Y, Lv X, Liu W, Judenhofer MS, Zwingenberger A, Wisner ER, Berg E, McKenney SE, Leung EK, Spencer BA, Cherry SR, Badawi RD Abstract As part of the EXPLORER total-body positron emission tomography (PET) project, we have designed and built a high-resolution, high-sensitivity PET/CT scanner which is expected to have excellent performance for companion animal whole body and human brain imaging. The PET component has a ring diameter of 52 cm and an axial field of view of 48.3 cm. The detector modules are composed of arrays of lutetium (yttrium) oxyorthosilicate (LYSO) crystals of dimensions 2.76x2.76x18.1 mm coupled to silicon photomultipliers (SiPMs) for read-out. The CT component is a 24 detector row CT scanner with a 50 kW X-ray tube. PET system time-of-flight resolution was measured to be 409±39 ps and average system energy resolution was 11.7%±1.5% at 511 keV. The NEMA NU2-2012 system sensitivity was found to be 52-54 kcps/MBq. Spatial resolution was 2.6 mm at 10mm from the center of the FOV and 2.0 mm rods were clearly resolved on a mini-Derenzo phantom. Peak noise-equivalent count (NEC) rate, using the NEMA NU 2-2012 phantom, was measured to be 314 kcps at 9.2 kBq/cc. The CT scanner passed the technical components of the American College of Radiology (ACR) accreditation ...
Source: Physics in Medicine and Biology - Category: Physics Authors: Tags: Phys Med Biol Source Type: research