Association of Corticosteroid Treatment With Outcomes in Adult Patients With Sepsis: A Systematic Review and Meta-analysis

This review of 37 RCTs (n=9,564) found that corticosteroid use was associated with reduced 28 day mortality (RR 0.90, 95% CI 0.82-0.88) vs placebo or standard supportive care. ICU mortality was also reduced (0.85, 0.77-0.94).
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news

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Publication date: Available online 16 August 2019Source: Reumatología Clínica (English Edition)Author(s): Ignacio Hernández Aragüés, C. Ana Villanueva Álvarez-Santullano, Ricardo Suárez Fernández, Ana Pulido Pérez
Source: Reumatologia Clinica - Category: Rheumatology Source Type: research
Authors: Muntoni F, Desguerre I, Guglieri M, Osorio AN, Kirschner J, Tulinius M, Buccella F, Elfring G, Werner C, Schilling T, Trifillis P, Zhang O, Delage A, Santos CL, Mercuri E Abstract Aim: Strategic Targeting of Registries and International Database of Excellence (STRIDE) is an ongoing, multicenter registry providing real-world evidence regarding ataluren use in patients with nonsense mutation Duchenne muscular dystrophy (DMD) in clinical practice (NCT02369731). Here, we describe the initial demographic characteristics of the registry population. Patients &methods: Patients will be followed up from en...
Source: Journal of Comparative Effectiveness Research - Category: General Medicine Tags: J Comp Eff Res Source Type: research
Conclusion: High-dose corticosteroids reduce nonrecovery in patients with Bell's palsy. The dose of high-dose corticosteroids was varied and further prospective study is needed to identify an adequate dose of corticosteroids in these patients.
Source: Otology and Neurotology - Category: ENT & OMF Tags: FACIAL NERVE Source Type: research
This article will discuss the available evidence on allergen immunotherapy and biologic drugs in pediatric asthma treatment. Expert opinion: Previously published studies demonstrated a good efficacy and safety profile of Allergen Immunotherapy in patients with mild-moderate asthma and sensitization to one main allergen. New understanding of mechanisms underlying severe asthma inflammation has allowed the identifications of specific biomarkers guiding the clinician in the choice of patient specific drug. Among the suggested immunotherapeutic options, omalizumab (blocking IgE) remains the first choice for atopic "early ...
Source: Expert Review of Respiratory Medicine - Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research
Conclusion: Macular abnormalities were associated with recurrent uveitis, course of disease and lower visual acuity at first visit. Regular treatment could prevent the development of macular abnormalities and improved visual outcome in most patients. PMID: 31415220 [PubMed - as supplied by publisher]
Source: Ocular Immunology and Inflammation - Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research
Conclusions: In the case of poor response to immunosuppressive therapy in elderly uveitis, infection including ARN should be considered. Immediate PCR testing for pathogen screening is required. PMID: 31414927 [PubMed - as supplied by publisher]
Source: Ocular Immunology and Inflammation - Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research
Publication date: Available online 15 August 2019Source: Comparative Biochemistry and Physiology Part C: Toxicology &PharmacologyAuthor(s): Karla Vagnerová, Peter Ergang, Matúš Soták, Kateřina Balounová, Pavlína Kvapilová, Martin Vodička, Jiří PáchaAbstractThe circadian clock system drives many physiological processes, including plasma concentration of glucocorticoids and epithelial transport of some ions and nutrients. As glucocorticoids entrain the circadian rhythms in various peripheral organs, we examined whether adrenalectomy affects the expression ...
Source: Comparative Biochemistry and Physiology Part C: Toxicology and Pharmacology - Category: Toxicology Source Type: research
DiscussionFindings of this trial will guide clinicians, programme managers and policymakers on the safety and efficacy of ACS in hospitals in low-resource countries. The trial findings will inform updating of the World Health Organization ’s global recommendations on ACS use.Trial registrationACTRN12617000476336. Registered on 31 March 2017.
Source: Trials - Category: Research Source Type: clinical trials
CD4+ T cell mediated uveitis has been treated with corticosteroids, immunosuppressive agents, and biologics targeting key inflammatory cytokines. However, many patients are resistant or intolerant to current therapies. Here, we investigated whether DNA methylation inhibitor zebularine can target CD4+ T cells and control intraocular inflammation. Our results showed that zebularine restrained the expression of inflammatory cytokines IFN- and IL-17 in both human and murine CD4+ T cells in vitro. Importantly, it also significantly alleviated intraocular inflammation and retinal tissue damage in the murine experimental autoi...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
ConclusionPlatelet-rich plasma could be effective treatment of mild to moderate idiopathic CTS and superior to corticosteroid in improving pain, function, and distal sensory latency of median nerve.Trial registrationClinicalTrials.gov Identifier: NCT03863873Key Points:•PRP is effective treatment of mild to moderate CTS.•PRP is superior to corticosteroids in improving pain and function in CTS.
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
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