What can rad onc residents expect in the job market?

What can radiation oncology residents expect to find in the job market upon...Read more on AuntMinnie.comRelated Reading: Proton therapy works well for pediatric brain tumors ASTRO: RT, surgery up stage IV lung cancer survival ASTRO: SABR is effective for oligometastatic cancers ASTRO: Weekly breast radiation therapy is safe ASTRO: AI's rad therapy future is in predicting outcomes
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news

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AbstractChanges in expression of histone deacetylases (HDACs), which epigenetically regulate chromatin structure, and mutations and amplifications of theEGFR gene, which codes for the epidermal growth factor receptor (EGFR), have been reported in glioblastoma (GBM), the most common and malignant type of brain tumor. There are likely interplays between HDACs and EGFR in promoting GBM progression, and HDAC inhibition can cooperate with EGFR blockade in reducing the growth of lung cancer cells. Here, we found that either HDAC or EGFR inhibitors dose-dependently reduced the viability of U87 and A-172 human GBM cells. In U87 ce...
Source: Journal of Molecular Neuroscience - Category: Neuroscience Source Type: research
Conclusionsl-1-[18F]FETrp highly accumulated in a wide range of malignancies including lung cancer, prostate cancer, and glioma. These results suggested thatl-1-[18F]FETrp is a promising radiotracer for PET imaging of cancer.
Source: Molecular Imaging and Biology - Category: Molecular Biology Source Type: research
CONCLUSIONS: Although overexpression of thioredoxin reductase (TrxR) and thioredoxin (Trx) is often linked to increased malignancy rate of brain tumors, and higher expression of glutathione (GSH) and glutathione S-Transferases (GST) are associated to resistance to therapy, several knowledge gaps still exist regarding for example, the role of peroxiredoxins (Prx), and glutaredoxins (Grx). CONCLUSION: Due to their central role in redox homeostasis and ROS scavenging, redox systems are potential targets for new antitumorals and examples of innovative therapeutics aiming at improving success rates in brain tumor treatment...
Source: Current Medicinal Chemistry - Category: Chemistry Authors: Tags: Curr Med Chem Source Type: research
AbstractAcquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors remains the main hurdle in treating EGFR-mutated lung cancer. Besides, when leptomeningeal carcinomatosis occurs during treatment, it often leads to treatment failure. We herein report a case of lung adenocarcinoma involving a patient with an EGFR exon 19 deletion mutation who developed leptomeningeal carcinomatosis after afatinib treatment for post-operative recurrence. He received right lower lobectomy, followed by four cycles of cisplatin and pemetrexed treatment. Follow-up CT/MRI revealed multiple pulmonary metastases and brain m...
Source: International Cancer Conference Journal - Category: Cancer & Oncology Source Type: research
Abstract Rapid advance in oncology leads to increasing survival of oncologic patients. More and more of them live long enough to reach either the natural age of menopause or, as a side effect of their oncotherapy, experience the cessation of gonadal function, leading to premature ovarian insufficiency, with disturbing vasomotor symtoms and long-term negative cardiovascular and skeletal effects. Thus, an ever increasing number of cancer survivors search endocrinologic help in the form of hormone replacement therapy (HRT). The misinterpretation of the WHI (Women's Health Initiative) Study has lead to an irrational f...
Source: Pathology Oncology Research - Category: Pathology Authors: Tags: Pathol Oncol Res Source Type: research
Is PET or MRI better for detecting tumor recurrence in patients with brain...Read more on AuntMinnie.comRelated Reading: DWI-MRI may be best for indeterminate lung nodules How effective is PET/MRI for rectal cancer? MRI shows promise for lung cancer screening Can whole-body MRI be used in oncologic staging?
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
ConclusionsDOACs can be safely administered to patients with brain tumors. In patients with primary brain tumors (i.e. glioma), DOACs appear to be safer than LMWH and should be considered for this indication.Figure.DisclosuresZwicker: Incyte: Research Funding; Parexel: Consultancy; Quercegen: Research Funding; Daiichi: Honoraria.
Source: Blood - Category: Hematology Authors: Tags: 332. Antithrombotic Therapy: Poster II Source Type: research
Conclusion: These findings suggest that SFN-NAC is a novel potential anti-glioma agent.Cell Physiol Biochem 2018;51:528 –542
Source: Cellular Physiology and Biochemistry - Category: Cytology Source Type: research
This study aimed to investigate the role of S100B in NSCLC brain metastasis. The results showed that serum S100B correlated significantly with NSCLC brain metastasis (P 
Source: Pathology Research and Practice - Category: Pathology Source Type: research
This study aimed to investigate the role of S100B in NSCLC brain metastasis. The results showed that serum S100B correlated significantly with NSCLC brain metastasis (P 
Source: Pathology, Research and Practice - Category: Pathology Authors: Tags: Pathol Res Pract Source Type: research
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