Total Knee Arthroplasty Is Safe in Jehovah's Witness Patients —A 12-Year Perspective

J Knee Surg DOI: 10.1055/s-0038-1676372Despite the evolution of blood management protocols, total knee arthroplasty (TKA) occasionally requires allogeneic blood transfusion. This poses a particular challenge for Jehovah's Witnesses (JW) who believe that the Bible strictly prohibits the use of blood products. The aim of this study was to compare JW and a matched-control cohort of non-JW candidates undergoing TKA to assess the safety using modern blood management protocols. Fifty-five JW patients (63 knees) who underwent TKA at our institution between 2005 and 2017 were matched to 63 non-JW patients (63 knees). Patient demographics, intraoperative details, and postoperative complications including in-hospital complications, revisions, and 90-day readmissions were collected and compared between the groups. Additionally, subgroup analysis was performed comparing JW patients who were administered tranexamic acid (TXA) between the two groups. Baseline demographics did not vary significantly between the study cohorts. The mean follow-up was 3.1 years in both the JW and non-JW cohorts. Postoperative complications, including in-hospital complications (7.9 vs. 4.8%; p = 0.47), revision TKA (1.6 vs. 1.6%; p = 1.00), and 90-day readmission (1.6 vs. 4.8%; p = 0.31) were not significantly different between the JW and non-JW groups. Subgroup analysis demonstrated JW patients who received TXA had a significantly lower decline in postoperative hemoglo...
Source: Journal of Knee Surgery - Category: Orthopaedics Authors: Tags: Original Article Source Type: research

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AbstractPurpose of ReviewCellular therapy started in the early twentieth century with the development of blood transfusion and later bone marrow transplantation. This review describes the historical origins and major milestones in the field of cellular therapy. We discuss ethical concerns associated with certain cell sources and how they influenced therapy strategies. A focus of this article is on the use of stem cells to understand regenerative repair after kidney injury. In addition, we give an overview over past and current kidney-related cellular therapy trials.Recent FindingsThe number of kidney-related cellular thera...
Source: Current Transplantation Reports - Category: Transplant Surgery Source Type: research
AbstractPurpose of reviewPatients with hemodynamically unstable pelvic fractures have a high mortality from pelvic hemorrhage. The purpose of this paper is to review preperitoneal pelvic packing (PPP) as an approach for these patients, including recent outcomes, and evaluation of treatment algorithms including angioembolization and resuscitative endovascular balloon occlusion of the aorta (REBOA).Recent findingsThere are no randomized clinical trials comparing PPP to other methods for controlling pelvic hemorrhage. The largest retrospective series, reporting on 128 patients, had a mortality rate of 21% and showed a reducti...
Source: Current Surgery Reports - Category: Surgery Source Type: research
Conclusion: To conclude, the occurrence of genotype 4 at a similar level to genotype 1 shows diffusion of new genotype in Kerala.
Source: Indian Journal of Medical Microbiology - Category: Microbiology Authors: Source Type: research
ConclusionThe DSS correlated significantly with operation time, blood loss and blood transfusion rate. These findings support the validity of the system.
Source: The American Journal of Surgery - Category: Surgery Source Type: research
Publication date: Available online 16 March 2019Source: European Journal of Surgical OncologyAuthor(s): Gaya Spolverato, Nicola Gennaro, Manuel Zorzi, Massimo Rugge, Claudia Mescoli, Mario Saugo, Maria Chiara Corti, Salvatore PucciarelliAbstractIntroductionFailure to rescue (FTR) patients from postoperative complications could contribute to the variability in surgical mortality seen among hospitals with different volumes. We sought to examine the impact of complications and FTR on mortality following rectal surgery.MethodsThe National Italian Hospital Discharge Dataset allowed identifying 75,280 patients who underwent rect...
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
This study tested the hypothesis that autologous blood transfusion (ABT) of ~50% of the red blood cells (RBC) from a standard 450-mL phlebotomy would increase mean power in a cycling time trial. In addition, the study investigated whether further ABT of RBC obtained from another 450-mL phlebotomy would increase repeated cycling sprint ability. Methods In a randomized, double-blind, placebo-controlled crossover design (3-month wash-out), nine highly trained male subjects donated two 450-mL blood bags each (BT trial) or were sham phlebotomized (PLA trial). Four weeks later, a 650-kcal time trial (n = 7) was performed 3 d ...
Source: Medicine and Science in Sports and Exercise - Category: Sports Medicine Tags: APPLIED SCIENCES Source Type: research
In patients supported by left ventricular assist devices (LVADs), half of all non-gastrointestinal bleeding (GIB)-related anemias are related to iron-deficiency (IDA). The clinical benefits of intravenous (IV) iron replacement in heart failure are well described, but there is a paucity of data regarding the treatment of IDA in LVAD patients. This pilot study aimed to determine the impact of IV ferric carboxymaltose (FCM) on anemia, blood transfusion requirements, readmissions,&functional capacity in the LVAD population.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: 253 Source Type: research
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Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: 812 Source Type: research
Peri-operative blood transfusions are associated with increased pulmonary morbidity and mortality. The impact of blood transfusions during lung transplantation surgery is largely unknown. We investigated the impact of intra-operative blood transfusions on acute rejection, post-transplant lung function and mortality in lung transplant recipients.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: 806 Source Type: research
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Source: Gastroenterology Research and Practice - Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research
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