From traditional biochemical signals to molecular markers for detection of sepsis after burn injuries

Publication date: February 2019Source: Burns, Volume 45, Issue 1Author(s): Balam Muñoz, Rocío Suárez-Sánchez, Oscar Hernández-Hernández, Rafael Franco-Cendejas, Hernán Cortés, Jonathan J. MagañaAbstractSepsis is a life-threatening organ-dysfunction condition caused by a dysregulated response to an infectious condition that can cause complications in patients with major trauma. Burns are one of the most destructive forms of trauma; despite the improvements in medical care, infections remain an important cause of burn injury-related mortality and morbidity, and complicated sepsis predisposes patients to diverse complications such as organ failure, lengthening of hospital stays, and increased costs. Accurate diagnosis and early treatment of sepsis may have a beneficial impact on clinical outcome of burn-injured patients. In this review, we offer a comprehensive description of the current and traditional markers used as indicative of sepsis in burned patients. However, although these are markers of the inflammatory post-burn response, they usually fail to predict sepsis in severely burned patients due to that they do not reflect the severity of the infection. Identification and measurement of biomarkers in early stages of infection is important in order to provide timely response and effective treatment of burned patients. Therefore, we compiled important experimental evidence, demonstrating novel biomarkers, including molecular markers such as genomic DNA variations, al...

Source: Burns - January 8, 2019 Category: Dermatology Source Type: research