Puerarin Reduces Blood Pressure in Spontaneously Hypertensive Rats by Targeting eNOS.

Puerarin Reduces Blood Pressure in Spontaneously Hypertensive Rats by Targeting eNOS. Am J Chin Med. 2019 Jan 07;:1-20 Authors: Shi W, Yuan R, Chen X, Xin Q, Wang Y, Shang X, Cong W, Chen K Abstract Puerarin is an isoflavonoid isolated from the root of Pueraria lobata (Gegen in Chinese) that has been widely used to treat cardiovascular and cerebrovascular diseases in China. Here, we investigated the hypotensive effects and mechanisms of puerarin in spontaneously hypertensive rats. The qPCR array technique was used to determine the expression of hypertension-related genes. Then, the differentially expressed genes were analyzed using the STRING database. The systolic blood pressure and diastolic blood pressure of rats decreased after the administration of puerarin for nine weeks. Puerarin, but not losartan, also slowed the heart rate of rats. NO and cGMP levels were improved by puerarin. Eighteen differentially expressed hypertension-related genes were identified by comparing the model group with the control group and the high-dose puerarin group with the model group. NO and cGMP levels were increased by high-dose puerarin. High-dose puerarin increased the levels of the phosphorylated eNOS protein and decreased AT1 and Cav1 levels. Based on our results, eNOS was a key target in the mechanism by which puerarin reduced blood pressure, and puerarin represents a potential antihypertensive agent. PMID: 30612457 [PubMed - as supplied by publisher]
Source: The American Journal of Chinese Medicine - Category: Complementary Medicine Authors: Tags: Am J Chin Med Source Type: research

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CONCLUSION: If the progression of the disease is noticeable in patients with glaucoma at follow-up, night-time hypotension should be ruled out with ambulatory blood pressure and if this is observed medical treatments used by the patients should be reviewed and necessary measures should be taken. PMID: 30650042 [PubMed - as supplied by publisher]
Source: Acta Cardiologica - Category: Cardiology Tags: Acta Cardiol Source Type: research
Authors: Șerban RC, Șuș I, Lakatos EK, Demjen Z, Ceamburu A, Fișcă PC, Somkereki C, Hadadi L, Scridon A Abstract BACKGROUND: Atrial fibrillation (AF) often complicates ST-segment elevation myocardial infarction (STEMI). Predictors of AF in this setting include factors related to the acute phase of STEMI and pre-existing conditions. More recently, novel AF predictors have been identified in the general population. We aimed to assess the ability of such novel factors to predict STEMI-related AF. METHODS: Data were collected from STEMI patients treated by primary PCI. Factors related to the acute phase of STE...
Source: Acta Cardiologica - Category: Cardiology Tags: Acta Cardiol Source Type: research
In this study, we aimed to investigate the relationship between ICAM-1 levels and the presence of fQRS in hypertensive patients. METHODS: Ninety consecutive patients who were diagnosed with hypertension were included in the study. ECG and transthoracic echocardiography were performed to all patients. fQRS was defined as additional R' wave or notching/splitting of S wave in two contiguous ECG leads. Serum ICAM-1 levels were measured using the enzyme-linked immunosorbent assay method. Patients were divided into two groups according to the presence of fQRS. RESULTS: A total of 90 patients (female, 65%; mean age: 54.6&...
Source: Acta Cardiologica - Category: Cardiology Tags: Acta Cardiol Source Type: research
Authors: Geis N, Raake P, Kiriakou C, Mereles D, Frankenstein L, Abu-Sharar H, Chorianopoulos E, Katus HA, Bekeredjian R, Pleger ST Abstract BACKGROUND: Incidence of stroke within 30 days after percutaneous mitral valve repair using the MitraClip varies from 0.7% and 2.6% between registries. Standard medical treatment after the MitraClip procedure, in the absence of risk factors requiring antithrombotic therapy such as atrial fibrillation, is dual antiplatelet therapy using aspirin and clopidogrel. ESC/EACTS and ACC/AHA surgical guidelines show a Class IIa indication for temporary antithrombotic therapy after ...
Source: Acta Cardiologica - Category: Cardiology Tags: Acta Cardiol Source Type: research
HIGH blood pressure symptoms aren ’t always easy to recognise - some can be mistaken for less serious health problems. But if the condition is left undiagnosed or untreated, life-threatening complications can develop. Three warning signs can easily be overlooked.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Publication date: Available online 17 January 2019Source: Surgery (Oxford)Author(s): Manj GohelAbstractThe management of patients with chronic leg ulcers represents an enormous burden to healthcare services in the United Kingdom. Most leg ulcers are due to chronic venous hypertension, although arterial compromise, malignancy, vasculitis and other medical disorders are also recognized causes. The assessment of patients with chronic leg ulceration should include a detailed history and clinical examination, supported by relevant investigations. Ankle-brachial pressure index measurement and non-invasive venous (± arteri...
Source: Surgery (Oxford) - Category: Surgery Source Type: research
Publication date: Available online 17 January 2019Source: European Journal of Surgical OncologyAuthor(s): Elbert J. Mets, Fouad K. Chouairi, Kyle S. Gabrick, Tomer Avraham, Michael AlperovichAbstractBackgroundRacial disparities among patients who receive breast mastectomy and reconstruction have not been well characterized.MethodsRecords of patients undergoing breast extirpative and reconstructive surgery at a high-volume university-affiliated hospital over 5 consecutive years were reviewed. Patient demographics, breast cancer profiles, reconstructive modality, and outcomes were compared by race.ResultsA total of 1045 pati...
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
Publication date: Available online 17 January 2019Source: Respiratory Physiology &NeurobiologyAuthor(s): Liu Zuoyou, Satomi Shiota, Yoshiteru Morio, Ai Sugiyama, Mitsuaki Sekiya, Shin-ichiro Iwakami, Hiroki Ienaga, Yoshinosuke Fukuchi, Kazuhisa TakahashAbstractPulmonary hypertension (PH) due to lung diseases is classified as group 3 by the Dana Point classification. Given the basic pathophysiological conditions of group 3 lung diseases and the previously well-known concept of hypercapnic pulmonary vasoconstriction, chronic hypercapnia besides alveolar hypoxia might be another causative factor to increase mean pulmonary...
Source: Respiratory Physiology and Neurobiology - Category: Respiratory Medicine Source Type: research
ConclusionThese results showed that vitamin D deficiency has a statistically significant relationship with preeclampsia and support the hypothesis that vitamin D deficiency may be a risk factor for preeclampsia.
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - Category: OBGYN Source Type: research
The objective of this study was to investigate whether the IOM's gestational weight gain guidelines are optimal for maternal and neonatal.Outcomes Study designWe included all consecutive twin pregnancies delivering two live births retrospectively. Monoamniotic pregnancies, major congenital abnormalities, twin-to-twin transfusion syndrome, patients with missing gestational weight gain data in the last month before delivery, and patients with a body mass index (BMI) ≤18.5 were excluded. To control for gestational length, we divided the total weight gain by the gestational age in weeks at the last weight measurement to obt...
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - Category: OBGYN Source Type: research
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