Total Glycosides of Peony Protects Against Inflammatory Bowel Disease by Regulating IL-23/IL-17 Axis and Th17/Treg Balance.

Total Glycosides of Peony Protects Against Inflammatory Bowel Disease by Regulating IL-23/IL-17 Axis and Th17/Treg Balance. Am J Chin Med. 2019 Jan 07;:1-25 Authors: Li Q, Shan Q, Sang X, Zhu R, Chen X, Cao G Abstract Inflammatory bowel disease (IBD) is a group of autoimmune diseases, including ulcerative colitis and Crohn's disease, characterized by nonspecific inflammation in the gut. Total glycoside of peony (TGP) has been widely used for treatment of autoimmune diseases because of its pharmacological effects. However, it is lack of depth in whether TGP regulate T helper 17 cell (Th17) / T regulatory cell (Treg) immune balance or interleukin 23 (IL-23) / IL-17 axis to achieve the goal of treating IBD. Hence, the aim of this study was to investigate the effects of TGP on experimental colitis mice and the related mechanisms. In the present study, we demonstrated that administration of TGP effectively attenuates colonic inflammation of TNBS-induced colitis mice, mainly reflected in significantly improved clinical parameters, reduced inflammatory response and myeloperoxidase (MPO) activity, even stronger systemic immune ability and effective improvement of Th17/Treg immune disorders. In addition, there was a stronger immunosuppressive ability in a positive cluster of differentiation 4 (CD4 + ) T-lymphocytes from the TGP treated mouse colon, characterized by the inhibition of high levels of inflammatory factors and increased regulatory T cells. Importantly...
Source: The American Journal of Chinese Medicine - Category: Complementary Medicine Authors: Tags: Am J Chin Med Source Type: research

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Conclusion: The frequency of hepatobiliary disorders was similar in both forms of IBD in patients evaluated. The most common nonspecific hepatobiliary manifestations in IBD patients were non-alcoholic liver disease and cholelithiasis. The most common specific hepatobiliary disorder was PSC in patients with extensive UC or ileocolonic CD involvement; this was seen more frequently in male patients. PMID: 30834274 [PubMed - in process]
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
Join us Tuesday evening, March 12th, at 8 pm EST/ 7 pm CST/6 pm MT/5 pm PT for my Undoctored SIBO Workshop: A 2-hour in-depth exploration of SIBO that I shall present via live video broadcast. The cost to attend is $55. An unprecedented number of people now have small intestinal bacterial overgrowth, SIBO, an intestinal condition that has reached epidemic proportions. SIBO causes or worsens numerous health conditions such as fibromyalgia, irritable bowel syndrome, ulcerative colitis, restless leg syndrome, ulcerative colitis and Crohn’s disease. If you have any of these conditions or have diabetes (typ...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: News & Updates Source Type: blogs
Because it has become such a frequent item in everyday meals, suggesting that something so commonplace must be fine, people often ask: Is wheat really that bad? Let’s therefore catalog the health conditions that are associated with wheat consumption. Health conditions we know with 100% certainty are caused by consumption of wheat and related grains: Celiac disease, dermatitis herpetiformis, cerebellar ataxia, “idiopathic” peripheral neuropathy, temporal lobe seizures, gluten encephalopathy, type 1 diabetes, rheumatoid arthritis, autoimmune hepatitis, autoimmune pancreatitis, tooth decay Health conditions ...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: News & Updates autoimmune diabetes gluten-free grain-free grains wheat wheat belly Source Type: blogs
DEVELOP is a multicenter, prospective, observational registry of the long-term safety and clinical outcomes of 6070 pediatric patients with inflammatory bowel disease (IBD; Crohn ’s disease, ulcerative colitis, or indeterminate colitis) treated with anti-tumor necrosis factor biologics (aTNF) and/or other medical therapies for IBD as part of routine clinical care. DEVELOP has sites in the United States, Canada and the European Union (EU). Our aim was to characterize the in cidence of new autoimmune disorders in a pediatric IBD population exposed to aTNF compared to a population exposed only to non-biologics.
Source: Gastroenterology - Category: Gastroenterology Authors: Tags: Disease Complications Source Type: research
Join us Wednesday evening, February 6th, at 8 pm EST/ 7 pm CST/6 pm MT/5 pm PT for my Undoctored SIBO Workshop: A 2-hour in-depth exploration of SIBO that I shall present via live video broadcast. The cost to attend is $55. (I will also be giving a SIBO Workshop for Undoctored Inner Circle members on Tuesday, February 5th at the same time slot.) An unprecedented number of people now have small intestinal bacterial overgrowth, SIBO, an intestinal condition that has reached epidemic proportions. SIBO causes or worsens numerous health conditions such as fibromyalgia, irritable bowel syndrome, ulcerative colitis, and...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: News & Updates bowel flora Inflammation microbiota probiotic silo small intestinal bacterial overgrowth undoctored Source Type: blogs
I’ve discussed the extremely important health condition, small intestinal bacterial overgrowth, or SIBO, a number of times, as it is present at epidemic proportions and for the most part not being diagnosed nor managed in conventional doctors’ offices. The Wheat Belly and Undoctored lifestyles provide a powerful start in reversing this condition, but additional steps are often necessary. A number of people in our Undoctored Inner Circle, for instance, have identified their own SIBO and then managed it successfully with the help of our Virtual Meetup discussions, even after doctors advised them that there is no ...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: News & Updates autoimmune candida candidiasis essential oils fungal Inflammation probiotic silo small intestinal bacterial overgrowth undoctored wheat belly Source Type: blogs
CONCLUSIONS: Patients reported multiple concerns about NMS that might impact treatment outcomes, and many of the patients who non-medically switched in this survey missed treatments. Future studies should be conducted on patient expectations and experiences with NMS to understand the impact on healthcare delivery, treatment persistency, and patient outcomes. The patient perspective and experience should be considered by decision-makers when developing coverage policies for biosimilar medications and associated communication strategies. PMID: 30618353 [PubMed - as supplied by publisher]
Source: Current Medical Research and Opinion - Category: Research Tags: Curr Med Res Opin Source Type: research
One of the reasons why the Wheat Belly lifestyle is so spectacularly effective for restoring health, losing weight, and turning back the clock a decade or two is because we reject the flawed logic of conventional nutritional advice. There is a long list of reasons why conventional nutritional advice gets it so wrong, from logical blunders, to relying on flawed observational evidence (rather than clinical trials), to getting too cozy with Big Food companies like Coca Cola and Kraft. Let’s discuss a common and widely-held blunder in logic that is applied over and over again in nutrition: If something bad is replaced by...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: News & Updates gluten-free grain-free grains undoctored wheat belly Source Type: blogs
Publication date: Available online 17 December 2018Source: Autoimmunity ReviewsAuthor(s): Laurent Peyrin-Biroulet, Stephen Demarest, Ajay NirulaAbstractTargeting various disease pathways using monoclonal antibodies (mAbs) has transformed the treatment paradigm for inflammatory bowel disease (IBD), with these agents exhibiting improved efficacy over corticosteroids or immunosuppressive therapies. Antibodies targeting tumor necrosis factor α (TNF-α) were the first approved biologics for IBD, followed by the more recent approval of antibodies targeting the α4β7 integrin heterodimer and ustekinumab, whic...
Source: Autoimmunity Reviews - Category: Allergy & Immunology Source Type: research
Iatrogenic lymphoproliferative disorders have been described in patients receiving immunosuppressive/immunomodulatory agents outside the transplantation setting. Novel biological agents such as TNF-α blockers and JAK-inhibitors have also proven to be effective in many disorders including rheumatoid arthritis, inflammatory bowel disease (ulcerative colitis and Crohn disease), psoriasis, and others. A significant dilemma exists in those lymphoproliferative disorders associated with immunosuppressants and rheumatologic conditions, that relies on whether the association of the process is with the medication or the underl...
Source: The American Journal of Surgical Pathology - Category: Pathology Tags: Case Report Source Type: research
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