HER2/neu (ERBB2) expression and gene amplification correlates with better survival in esophageal adenocarcinoma

HER2 (ERBB2 or HER2/neu) is a tyrosine-kinase increasing cell proliferation. Overexpression/amplification of HER2 is correlated with worse prognosis in solid malignancies. Consequently, HER2 targeting is estab...

Source: BMC Cancer - January 8, 2019 Category: Cancer & Oncology Authors: Patrick Sven Plum, Florian Gebauer, Max Kr ämer, Hakan Alakus, Felix Berlth, Seung-Hun Chon, Lars Schiffmann, Thomas Zander, Reinhard Büttner, Arnulf Heinrich Hölscher, Christiane Josephine Bruns, Alexander Quaas and Heike Loeser Tags: Research article Source Type: research