Expression and potential role of cellular retinol binding protein I in psoriasis.

Expression and potential role of cellular retinol binding protein I in psoriasis. Oncotarget. 2018 Dec 04;9(95):36736-36749 Authors: Costanza G, Doldo E, Ferlosio A, Tarquini C, Passeri D, Cascella R, Bavetta M, Di Stefani A, Bonifati C, Agostinelli S, Centofanti F, Giardina E, Campione E, Bianchi L, Donati P, Morrone A, Orlandi A Abstract Psoriasis is a diffuse chronic skin disorder characterized from accelerated epidermal turnover and inflammatory cell infiltrate. Retinoids influence keratinocyte proliferation and differentiation as well as inflammatory response. Cellular retinol binding protein (CRBPI) regulates intracellular vitamin A bioavailability and contributes to maintain skin homeostasis. The aim of present study was to investigate the expression of CRBPI and its role in the pathogenesis of skin psoriasis. Immunohistochemistry revealed more diffuse and increased CRBPI expression in all epidermal layers of human psoriatic lesions except in the stratum corneum. An imiquimod-induced psoriatic-like model documented the increase of skin lesional area and severity index score as well as of the severity of microscopic features as parakeratosis, papillomatosis and spongiosis in CRBPI-knockout compared to wild-type mice, associated to the increased keratinocyte CK17 and Ki-67 expression and the reduction of CK1, CRABPII and RXRα. Gene array of imiquimod-induced psoriatic skin documented the greater up-regulation of EGF/PDGF-relate...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research