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Source: OnMedica Latest News - Category: UK Health Source Type: news

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ConclusionThe decline in MRSA BSI rates, which was observed in our institution, was associated with changes in the population structure of the organism. This decline may be related to biologic properties of the prevailing MRSA clones.
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
Over the past 20 years there have been two dominant pandemic healthcare-associated methicillin-resistant Staphylococcus aureus (HA-MRSA) clones in the UK, EMRSA –15 (ST22) and EMRSA-16 (ST36), with lower prevalence of other clones (ST8, ST239, ST5 and ST247). HA-MRSA rates have decreased significantly since the mid-2000s1–4 following the introduction of a comprehensive UK-wide infection control program comprising re-enforcement of basic infection contro l practices and targeted measures of screening, contact precautions, patient isolation and decolonization.
Source: Journal of Infection - Category: Infectious Diseases Authors: Source Type: research
Over the past 20 years there have been two dominant pandemic healthcare-associated methicillin-resistant Staphylococcus aureus (HA-MRSA) clones in the UK, EMRSA –15 (ST22) and EMRSA-16 (ST36), with lower prevalence of other clones (ST8, ST239, ST5 and ST247). HA-MRSA rates have decreased significantly since the mid-2000’s 1–4 following the introduction of a comprehensive UK-wide infection control program comprising re-enforcement of basic infection co ntrol practices and targeted measures of screening, contact precautions, patient isolation and decolonization.
Source: Journal of Infection - Category: Infectious Diseases Authors: Source Type: research
Discussion: The genomic diversity of Gaza ST22 isolates is not consistent with recent emergence in the region. The results indicate that two divergent Gaza clones evolved separately from susceptible isolates. Researchers should not assume that isolates identified as ST22 in the community are examples of EMRSA-15 that have escaped their healthcare roots. Future surveillance of MRSA is essential to the understanding of ST22 evolutionary dynamics and to aid efforts to slow the further spread of this lineage. PMID: 30153881 [PubMed - in process]
Source: Euro Surveill - Category: Infectious Diseases Authors: Tags: Euro Surveill Source Type: research
Authors: Tfifha M, Ferjani A, Mallouli M, Mlika N, Abroug S, Boukadida J Abstract The pandemic spread of multidrug-resistant (MDR) bacteria (i.e., methicillin-resistant Staphylococcus aureus (MRSA), extended-spectrum b-lactamase-producing Enterobacteriaceae (ESBLPE), vancomycin-resistant enterococci, carbapenemase-producing Enterobacteriaceae (CPE), multiresistant Pseudomonas aeruginosa and multiresistant Acinetobacter baumannii) pose a threat to healthcare Worldwide. We found limited data of MDR bacteria in pediatric patients hospitalized in Tunisian tertiary healthcare.The aim of the study is to evaluate the acqu...
Source: Libyan Journal of Medicine - Category: General Medicine Tags: Libyan J Med Source Type: research
USA300 is a pandemic clonal lineage of hypervirulent, community-acquired, methicillin-resistant Staphylococcus aureus (CA-MRSA) with specific molecular characteristics. Despite its high clinical relevance, the evolutionary origin of USA300 remained unclear. We used comparative genomics of 224 temporal and spatial diverse S. aureus isolates of multilocus sequence type (ST) 8 to reconstruct...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Tags: PNAS Plus Source Type: research
Influenza A virus (IAV) infection is often followed by secondary bacterial lung infection, which is a major reason for severe, often fatal pneumonia. Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) strains such as USA300 cause particularly severe and difficult-to-treat cases of IAV-associated pneumonia. CA-MRSA strains are known to produce extraordinarily large amounts of phenol-soluble modulin (PSM) peptides, which are important cytotoxins and proinflammatory molecules that contribute to several types of S. aureus infection. However, their potential role in pneumonia has remained elusive. We det...
Source: Infection and Immunity - Category: Infectious Diseases Authors: Tags: Molecular Pathogenesis Source Type: research
Conclusions The prevalence of S aureus and MRSA nasal colonization was moderate. The molecular characteristics of S aureus and MRSA isolates indicated possible cross-transmission among multiple resources. A higher frequency of daily handwashing and weekly bathing significantly decreased the prevalence of S aureus and MRSA CC5 nasal colonization in the pregnant women.
Source: American Journal of Infection Control - Category: Infectious Diseases Source Type: research
In this study we aimed to identify evolutionary steps linking thesemecA precursors to the β-lactam resistance genemecA and the resistance phenotype. We sequenced genomes of 106S.sciuri,S.vitulinus andS.fleurettii strains and determined their oxacillin susceptibility profiles. Single-nucleotide polymorphism (SNP) analysis of the core genome was performed to assess the genetic relatedness of the isolates. Phylogenetic analysis of themecA gene homologues and promoters was achieved through nucleotide/amino acid sequence alignments and mutation rates were estimated using a Bayesian analysis. Furthermore, the predicted stru...
Source: PLoS Genetics - Category: Genetics & Stem Cells Authors: Source Type: research
ConclusionsIn this small study, we report for the first time of the occurrence of diverse MRSA genotypes belonging to both pandemic and more sporadic international clones in Armenia harbouring the smaller SCCmec types and/or ACME, both of which have been associated with strain fitness. Further surveillance is warranted to better understand the prevalence, clinical and molecular epidemiology of MRSA throughout Armenia.
Source: Antimicrobial Resistance and Infection Control - Category: Infectious Diseases Source Type: research
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