Medical and Surgical Management of Rheumatoid Arthritis of the Spine

No abstract available
Source: Contemporary Spine Surgery - Category: Orthopaedics Tags: CME Quiz Source Type: research

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Publication date: Available online 15 February 2020Source: Best Practice &Research Clinical RheumatologyAuthor(s): Lucas L. van den Hoogen, Jacob M. van LaarAbstractTargeted therapies using biological disease-modifying antirheumatic drugs (bDMARDs) and small molecule synthetic drugs have revolutionized rheumatological practice. Initially developed for the treatment of immune arthritis (rheumatoid arthritis, psoriatic arthritis, and spondylarthritis), both bDMARDs and small molecule synthetic drugs are now increasingly entering the space of connective tissue disease (CTD) treatment. Recent clinical trial data in systemi...
Source: Best Practice and Research Clinical Rheumatology - Category: Rheumatology Source Type: research
No abstract available
Source: Lippincott's Bone and Joint Newsletter - Category: Orthopaedics Tags: Trends and Innovations Source Type: news
CONCLUSION: RA patients treated with IL-6 antibody show a better response when they have sufficient serum vit D. Tocilizumab and 1,25(OH)₂D synergistically suppress IL-17 production and osteoclast differentiation in RA patients. PMID: 32056400 [PubMed - in process]
Source: Journal of Korean Medical Science - Category: Biomedical Science Tags: J Korean Med Sci Source Type: research
Authors: Liu Y, Wu Y, Gu S, Yin Q, Li H, Wang J, Geng D, Xu Y Abstract Activation of the P2X7 receptor (P2X7R) has been found to increase expression of tumor necrosis factor-α (TNF-α) in the joints and synovial lining of patients with rheumatoid arthritis (RA). Increased expression of TNF-α promotes joint destruction through deterioration of type II collagen by matrix metalloproteinases (MMPs), expression of proinflammatory cytokines, oxidative stress, and activation of cellular signaling pathways. In the present study, we exposed fibroblast-like synoviocytes (FLSs) to TNF-α in the presence ...
Source: American Journal of Translational Research - Category: Research Tags: Am J Transl Res Source Type: research
Authors: Balbaloglu O, Ozcan SS Abstract Introduction: The aim of the current study was to identify whether serum pentraxin 3 (PTX3) level could be a marker of increased inflammation in rheumatoid arthritis (RA) patients. Material and methods: The study included 41 patients diagnosed with RA according to the American College of Rheumatology (ACR) 1990 diagnostic criteria. We compared the serum PTX3 levels between RA patients and a healthy control group, the relationship between PTX3 level and disease activity was also examined. Results: A statistically significant difference was determined between the RA pa...
Source: Archives of Medical Science - Category: General Medicine Tags: Arch Med Sci Source Type: research
ConclusionsSatisfaction and fulfilment of expectations were high. Fulfilment of expectations of tolerability was better with monthly administration, which could contribute to better adherence.ResumenObjetivosEn el estudio ARCO, la adherencia al biológico subcutáneo en pacientes con artritis reumatoide fue mejor con administración mensual. Evaluamos si satisfacción y cumplimiento de expectativas pueden relacionarse con la adherencia al tratamiento.Pacientes y métodosLa adherencia se evaluó calculando el Índice de Posesión de Medicación, y satisfacción y c...
Source: Reumatologia Clinica - Category: Rheumatology Source Type: research
AbstractPain is a health issue affecting all populations, regardless of age, gender, economic status, race, or geography. Acute pain is the most common type of pain, with a complex aetiology. Inadequately managed acute pain adversely affects quality of life and imposes significant economic burden. The majority of the available pain-relieving drugs have monomodal mechanisms of analgesia, which necessitates combining drugs with non-redundant mechanisms of action in order to provide adequate pain relief and reduce the side effects from higher doses of individual drugs. In this regard, combining an oral opioid (such as codeine...
Source: Pain and Therapy - Category: Anesthesiology Source Type: research
AbstractPurpose of ReviewThe past decade in LGL leukemia research has seen increased pairing of clinical data with molecular markers, shedding new insights on LGL leukemia pathogenesis and heterogeneity. This review summarizes the current standard of care of LGL leukemia, updates from clinical trials, and our congruent improved understanding of LGL pathogenesis.Recent FindingsVarious clinical reports have identified associations between stem, bone marrow, and solid organ transplants and incidence of LGL leukemia. There is also a potential for underdiagnosis of LGL leukemia within the rheumatoid arthritis patient population...
Source: Current Hematologic Malignancy Reports - Category: Hematology Source Type: research
ConclusionsAndrographolide acts as a protective agent for the treatment of complete freund's adjuvant induced rheumatoid arthritis by inhibiting lipid peroxidation and nitrite/nitrate levels in a dose-dependent manner, enhancing antioxidant enzyme activity, reducing levels of chemokines and inflammatory factors, preventing neutrophil accumulation and infiltration.Graphical abstract
Source: Chemico Biological Interactions - Category: Biochemistry Source Type: research
Publication date: Available online 13 February 2020Source: Sensors and Actuators B: ChemicalAuthor(s): Mahnaz D. Gholami, Prashant Sonar, Godwin A. Ayoko, Emad L. IzakeAbstractTumor necrosis factor alpha (TNF-α) is a cytokine that plays a critical role in medical conditions such cardiovascular diseases, rheumatoid arthritis, inflammatory bowel disease, Alzheimer’s and cancer. Herein, we present a new method for the determination of TNF-α by surface enhanced Raman spectroscopy (SERS). A new benzothiazole azo dye (BAN) was used as a Raman probe to detect the cytokine after its selective extraction from bloo...
Source: Sensors and Actuators B: Chemical - Category: Chemistry Source Type: research
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