The paramount role of cytokines and chemokines in papillary thyroid cancer: a review and experimental results

In conclusion, in PTC cells: (a) IFNγ+TNFα induced a marked release of CXCL9 and CXCL11; (b) PPARγ agonists stimulated CXCL9 and CXCL11 secretion, while inhibited proliferation; (c) CXCL9 and CXCL11 inhibited proliferation and migration. The use of CXCL9 or CXCL11 as antineopla stic agents in PTC remains to be explored.Highlights• IFNγ and IFNγ+TNFα induce dose-dependently CXCL9 (and less CXCL11) in PTC cells.• Rosi and Pio dose-dependently inhibit the PTC cells proliferation.• Rosi and Pio (at variance of normal TFC) stimulate CXCL9 or CXCL11 secretion.• CXCL9 or CXCL11 induce a significant antiproliferative effect in PTC cells.• Chemokines induced by IFNγ (CXCL9 or CXCL11) inhibit migration in PTC cells.
Source: Immunologic Research - Category: Allergy & Immunology Source Type: research