Hydroxocobalamin Treatment of Refractory Vasoplegia in Patients with Mechanical Circulatory Support

Vasoplegic syndrome (VS) is a type of vasodilatory shock defined by a constellation of a high cardiac output state, low systemic vascular resistance (SVR), low filling pressures, and low mean arterial pressure (MAP) despite high-dose vasoconstrictors. It is a well-known phenomenon following cardiopulmonary bypass (CPB), with a reported incidence of 8-10%,1 and is more common following left ventricular assist device (LVAD) placement (42%).2 VS is associated with significant morbidity and a mortality rate ranging from 16-27%.

Source: The Journal of Heart and Lung Transplantation - January 7, 2019 Category: Transplant Surgery Authors: Theodore J. Cios, Benjamin Havens, Behzad Soleimani, S. Michael Roberts Tags: Research Correspondence Source Type: research