Opioid Rx Tied to Pneumonia Risk

(MedPage Today) -- Irrespective of HIV status; tied mainly to certain agents and high doses
Source: MedPage Today Infectious Disease - Category: Infectious Diseases Source Type: news

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Conclusion: The use of the Seal thoracic stent graft yielded good mid-term results. Further studies are needed to examine the long-term outcomes of this device. PMID: 31624711 [PubMed]
Source: Korean Journal of Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Tags: Korean J Thorac Cardiovasc Surg Source Type: research
Publication date: December 2019Source: Molecular Immunology, Volume 116Author(s): Mahya Ranjbar, Bahador Behrouz, Fatemeh Norouzi, Seyed Latif Mousavi GargariAbstractPseudomonas aeruginosa is a common nosocomial pathogen in burn patients, and rapidly acquires antibiotic resistance; thus, developing an effective therapeutic approach is the most promising strategy for combating infection. Type III secretion system (T3SS) translocates bacterial toxins into the cytosol of the targeted eukaryotic cells, which plays important roles in the virulence of P. aeruginosa infections in both acute pneumonia and burn wound models. The Pc...
Source: Molecular Immunology - Category: Allergy & Immunology Source Type: research
ConclusionsWith the application of a dual model, there appears to be no significant difference in mortality of obese patients with pneumonia compared to normal BMI patients with pneumonia.
Source: Obesity Research and Clinical Practice - Category: Eating Disorders & Weight Management Source Type: research
Publication date: Available online 18 October 2019Source: Carbohydrate PolymersAuthor(s): Chunbo Lu, Yao Xiao, Yinyin Liu, Feifei Sun, Yuanhao Qiu, Haibo Mu, Jinyou DuanAbstractAntibiotics are powerful weapons to fight against bacterial infections, while most of them lack of selective targeting towards pathological site which could restrict their antibacterial efficacy. To overcome this challenge, an antimicrobial levofloxacin(LF)was conjugated onto hyaluronic acid (HA) moieties via an o-phenylenediamine linker to prepare a NO-sensitive nanosystem (HA-NO-LF) in this study. The HA-NO-LF nanomicelles could enter host cells v...
Source: Carbohydrate Polymers - Category: Biomedical Science Source Type: research
Once considered a safer alternative to cigarettes, radiologists are now drawing connections between vaping and lung injury patterns, according to a  studypublished this month in theAmerican Journal of Roentgenology. This isn ’t the first time that radiologists are voicing concerns about the adverse effects of e-cigarettes. A magnetic resonance imaging (MRI) studypublished in August showed that a single session of vaping causes reduced blood flow and damaged vascular reactivity in the femoral artery. The researchers also found that the vaping solution consists of potentially harmful chemicals that when ...
Source: radRounds - Category: Radiology Authors: Source Type: blogs
Authors: Schöll N, Rohde GGU Abstract Pneumonia belongs to the most frequent and most deadly infectious diseases worldwide. It represents an increasing problem for the aging population. The incidence and mortality rises with every decade. The clinical presentation of pneumonia differs between elderly and younger patients. Multiple factors including functional status (self-dependency and immobilization), comorbidities, immunosenescence, nutritional status, swallowing disorders have to be accounted for. Pneumonia in the elderly has to be differentiated from nursing home acquired pneumonia. Diagnosis of pneumonia...
Source: Pneumologie - Category: Respiratory Medicine Tags: Pneumologie Source Type: research
In this review, we report the available data regarding efficacy, safety and pharmacokinetics of colistin in the treatment of multidrug-resistant Gram-negative bacteria in neonates and infants. Seventeen clinical studies, involving 312 patients, and 3 pharmacokinetics studies were identified. Blood stream infection was the most common source of infection, followed by pneumonia and meningitis/ventriculitis. In most cases, colistin was administered in association with other antibiotics. The most common route of administration was intravenous, with colistimethate doses ranging from 25,000 to 225,000 IU/kg/day divided into 2 or...
Source: The Pediatric Infectious Disease Journal - Category: Infectious Diseases Tags: Antimicrobial Reports Source Type: research
Publication date: 5 February 2020Source: Journal of Molecular Structure, Volume 1201Author(s): Rasha A. Azzam, Galal H. Elgemeie, Rokia R. OsmanAbstractThe synthesis of novel pyrido[2,1-b]benzothiazole and pyrido[2,1-b]benzoimidazole derivatives was achieved via the reaction of N-aryl-2-cyano-3,3-bis(methylthio)acrylamide with benzothiazoleylacetonitrile and benzoimidazoleylacetonitrile, respectively, while N-substituted 2-pyridylbenzothiazole derivatives were synthesized by reacting 2-(benzo[d]thiazol-2-yl)-3-(dimethylamino)acrylonitrile with either cyanoacetamide, aryl cyanoacetamides or 2-cyano-N’-(4-substituted b...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
Publication date: Available online 17 October 2019Source: The Lancet Respiratory MedicineAuthor(s): The Lancet Respiratory Medicine
Source: The Lancet Respiratory Medicine - Category: Respiratory Medicine Source Type: research
Jared Dunnmon Luke Oakden-Rayner By LUKE OAKDEN-RAYNER MD, JARED DUNNMON, PhD Medical AI testing is unsafe, and that isn’t likely to change anytime soon. No regulator is seriously considering implementing “pharmaceutical style” clinical trials for AI prior to marketing approval, and evidence strongly suggests that pre-clinical testing of medical AI systems is not enough to ensure that they are safe to use.  As discussed in a previous post, factors ranging from the laboratory effect to automation bias can contribute to substantial disconnects between pre-clinical performance of AI sys...
Source: The Health Care Blog - Category: Consumer Health News Authors: Tags: Artificial Intelligence Data Health Tech Health Technology AI Jared Dunnmon Luke Oakden-Rayner machine learning Source Type: blogs
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