Alcohol Is Harder To Handle As You Age, Expert Says

COLUMBUS, OHIO (CBS) – It only gets harder for adults to handle alcohol as they get older, according to an addiction medicine specialist. Aging also makes people more vulnerable to alcoholism, he says. Ohio State University clinical psychologist Brad Lander writes that older people process alcohol less efficiently in their bodies than when they were younger. “As we age, it takes longer for the body to break down alcohol,” he says. “It stays in the system longer. Tolerance also decreases.” Lander says that among seniors, women are more likely than men to develop alcoholism. And while younger people might be more likely to drink in social situations, seniors can up their consumption to “seek relief from the bored, loneliness and grief that are common with aging.” Excessive drinking is associated with a number of health problems that are complicated by aging, according to Lander. That includes cancer, balance problems that can lead to more falls, diabetes, high blood pressure, liver problems, early-onset dementia, depression and decreased sexual functioning. The average senior should not have more than three drinks in one day or seven drinks per week, Lander says. How much drinking is cause for concern? “The general rule of thumb is to take a close look and honestly assess if drinking is causing any life problems,” Lander says. “If it’s causing difficulties with your health, relationships, daily functioning or emo...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Health News Alcohol Local TV Source Type: news

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Publication date: Available online 23 March 2019Source: NeuroImageAuthor(s): Sharmili Edwin Thanarajah, Sandra Iglesias, Bojana Kuzmanovic, Lionel Rigoux, Klaas E. Stephan, Jens C. Brüning, Marc TittgemeyerAbstractInsulin modulates dopamine neuron activity in midbrain and affects processes underlying food intake behaviour, including impulsivity and reward processing. Here, we used intranasal administration and task-free functional MRI in humans to assess time- and dose-dependent effects of insulin on functional connectivity of the dopaminergic midbrain – and how these effects varied depending on systemic insulin...
Source: NeuroImage - Category: Neuroscience Source Type: research
Publication date: Available online 23 March 2019Source: The Annals of Thoracic SurgeryAuthor(s): Donglai Chen, Yiming Mao, Junmiao Wen, Yunlang She, Erjia Zhu, Feng Zhu, Yongsheng Zhang, Min Fan, Chang Chen, Yongbing ChenAbstractBackgroundA series of studies have assessed the clinicopathological features and prognostic impact of STAS in non-small cell lung cancer (NSCLC) bringing conflicting findings so far. We performed a systematic review and meta-analysis to synthesize the available evidence regarding to the prognostic value of STAS in NSCLCs.MethodsStudies were identified by searching databases including PubMed, EMBASE...
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
CONCLUSIONS: Adolescents and young adults with bipolar disorder exhibited an increased risk of subsequent STI during the follow-up period compared with those without bipolar disorder. Comorbidity of substance and alcohol use disorders further increased this risk. Long-term use of bipolar disorder medications (mood stabilizers and atypical antipsychotics) may reduce this risk. PMID: 30901168 [PubMed - in process]
Source: Journal of Clinical Psychiatry - Category: Psychiatry Tags: J Clin Psychiatry Source Type: research
CONCLUSIONS: Polypharmacy is significantly associated with delirium only in surgical units, raising the issue of the relevance of medication review in different clinical settings. Specific drug classes are associated with delirium depending on the clinical setting and dementia diagnosis, suggesting the need to further explore this relationship. PMID: 30901165 [PubMed - in process]
Source: Journal of Clinical Psychiatry - Category: Psychiatry Tags: J Clin Psychiatry Source Type: research
Authors: Goldfarb D, Sheard S, Shaughnessy L, Atri A Abstract Disclosing the diagnosis of cognitive impairment or dementia due to Alzheimer's disease (AD) and Related Dementias (ADRD) can be one of the most challenging aspects of dementia care for clinicians. However difficult the diagnosis is to give or receive, evidence and evidence-based consensus support that disclosing a timely AD/ADRD diagnosis, accompanied by psychoeducation and care planning, is beneficial to patient-care partner dyads. Diagnosis, provided as early as possible, increases the likelihood for patients to be involved in decision-making and plan...
Source: Journal of Clinical Psychiatry - Category: Psychiatry Tags: J Clin Psychiatry Source Type: research
CONCLUSIONS: CCBT with a modest amount of support from a clinician or other helping person was found to be efficacious with relatively large mean effect sizes on measures of depressive symptoms. Self-guided CCBT for depression was considerably less effective. Future research should focus on enhancing the implementation of CCBT, including evaluating the amount and type of support needed for effective delivery, methods to improve engagement with computer-assisted therapies, and ways to improve treatment outcome in primary care settings. PMID: 30900849 [PubMed - in process]
Source: Journal of Clinical Psychiatry - Category: Psychiatry Tags: J Clin Psychiatry Source Type: research
This study represents a pooled analysis from the control arms of two clinical trials (NCT00290966; NCT00678535). Both control arms evaluated fluoropyrimidine/cisplatin combination in the first line treatment of advanced gastric cancer. Univariate and multivariate Cox regression analyses were performed to assess factors affecting overall and progression-free survival. Factors with P
Source: Expert Review of Pharmacoeconomics and Outcomes Research - Category: Health Management Tags: Expert Rev Pharmacoecon Outcomes Res Source Type: research
CONCLUSIONS: The large, sustained improvements in weight and diabetes observed in this self-selected sample of surgically treated participants are consistent with results of multiple randomized trials. PMID: 30900413 [PubMed - in process]
Source: Obesity - Category: Eating Disorders & Weight Management Authors: Tags: Obesity (Silver Spring) Source Type: research
Authors: PMID: 30900407 [PubMed - in process]
Source: Obesity - Category: Eating Disorders & Weight Management Tags: Obesity (Silver Spring) Source Type: research
Publication date: Available online 24 March 2019Source: Journal of Molecular LiquidsAuthor(s): Achal Mukhija, Nand KishoreAbstractBiocompatibility and ease of surface modification make gold nanoclusters potential to be used in nanomedicine and revolutionizing cancer therapy. Low solubility and bioavailability of drug limits the use of conventional drug administrative methods and hence the need for drug delivery vehicles arises. Different drug delivery vehicles have been used in the past but usually, the information is limited to qualitative in nature. Here, we have reported quantitative insights into interaction of human s...
Source: Journal of Molecular Liquids - Category: Molecular Biology Source Type: research
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