Loss of Wnt secretion by macrophages promotes hepatobiliary injury following administration of DDC diet.

In conclusion, this study shows that a lack of macrophage Wnt secretion leads to more DDC-induced hepatic injury due to impaired hepatocyte proliferation and increased M1 macrophages, which promotes immune-mediated cell injury.
PMID: 30610845 [PubMed - as supplied by publisher]

Source: The American Journal of Pathology - January 2, 2019 Category: Pathology Authors: Jiang A, Okabe H, Popovic B, Preziosi ME, Pradhan-Sundd T, Poddar M, Singh S, Bell A, England SG, Nagarajan S, Monga SP Tags: Am J Pathol Source Type: research