Deficiency of Bmal1 disrupts the diurnal rhythm of haemostasis.

CONCLUSION: Bmal1 deficiency affected the biphasic rhythm of coagulation and fibrinolysis factors predominantly in the liver. In the brain, Bmal1-dependent control of t-PA gene expression was documented for the first time. PMID: 30610898 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/30610898?dopt=Abstract

Source: Experimental Gerontology - January 2, 2019 Category: Geriatrics Authors: Hemmeryckx B, Frederix L, Roger Lijnen H Tags: Exp Gerontol Source Type: research