Exosome-Transmitted PSMA3 and PSMA3-AS1 Promotes Proteasome Inhibitors Resistance in Multiple Myeloma.

CONCLUSION: This study suggested a unique role of exosomal PSMA3 and PSMA3-AS1 in transmitting PIs resistance from MSCs to MM cells, through a novel exosomal PSMA3-AS1/PSMA3 signaling pathway. Exosomal PSMA3 and PSMA3-AS1 might act as promising therapeutic targets for PIs resistance and prognostic predictors for clinical response. PMID: 30610101 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/30610101?dopt=Abstract

Source: Clinical Cancer Research - January 4, 2019 Category: Cancer & Oncology Authors: Xu H, Han H, Song S, Yi N, Qian C, Qiu Y, Zhou W, Hong Y, Zhuang W, Li Z, Li B, Zhuang W Tags: Clin Cancer Res Source Type: research