Delisting HCV-infected Liver Transplant Candidates After SVR Delisting HCV-infected Liver Transplant Candidates After SVR
One in four cirrhosis patients on the waiting list for liver transplantation can be delisted after successful treatment with DAAs. How do they fare in the long-term?Liver International
Conclusion: Our data indicate that the risk of microvascular invasion is highest in tumors localized to segment 8. The size and number of HCC tumors were not associated with an increased risk of microvascular invasion. PMID: 31186641 [PubMed]
ConclusionAlthough LT is feasible for patients with HPS, early transplantation and avoiding hypo ‐oxygenemia immediately after transplantation are important.
Conclusion TIPS combined with antegrade embolization is safe, effective, and feasible for patients with SPSSs, with safety and long-term outcomes comparable to patients without SPSSs.
ConclusionSurvival in DC was shorter than what was expected in the natural history of the disease after GCSF use.
CONCLUSIONS: MSC treatment improves liver function, decreases hepatic fibrosis, and plays an anti-inflammatory role; it promotes HGF levels and increased proliferating cell nuclear antigen when followed by MSC treatment mobilization using G-CSF. When these therapies were combined, however, fibrosis improvement was less evident. PMID: 31147180 [PubMed - as supplied by publisher]
AbstractNonalcoholic steatohepatitis (NASH) is a chronic, progressive disease, that can advance to fibrosis, cirrhosis, and hepatocellular carcinoma. Despite being a leading cause of liver transplantation, there are no approved pharmacological treatments. Our aim was to identify literature on management options in NASH. Our structured review of interventions treating NASH patients from English language publications between 1 January 2007 and 25 September 2017 elicited 48 eligible references. Lifestyle management was identified as the mainstay of NASH therapy. Vitamin E and pioglitazone reported reductions in steatosis; how...
ConclusionPatients within Milan criteria have acceptable RFS even in the presence of poor prognostic factors. However, the presence of two or more poor prognostic variables significantly impacts RFS of patients outside Milan criteria.
Publication date: May 2019Source: Cytotherapy, Volume 21, Issue 5, SupplementAuthor(s): M. Chan, A. Gomez-Aristizabal, R. Rabani, R. Gandhi, W. Marshall, N. Mahomed, S. ViswanathanBackground &AimMonocytes/macrophages (MΦs) are innate immune cells that exist on a spectrum of pro-inflammatory to inflammation-resolving phenotypes. Their polarization is mediated in vivo through the local microenvironment or ex vivo through exogenous factors. Such ex vivo polarized cells have been used in early clinical trials for a variety of immunosuppressive or reparative indications (e.g. spinal cord injury, liver cirrhosis, transpl...
CONCLUSION: Patients who attended the first post-discharge TCLC appointment had a trend for higher liver transplant eligibility at 1 year. Being accompanied by family or friends during the first TCLC visit correlated with higher liver transplant eligibility at 1 year (attendance by family or friends was not requested). Patient and family engagement in the immediate post-hospitalization period may predict future liver transplant eligibility for patients previously declined. PMID: 31114641 [PubMed]
Authors: Oikonomou T, Goulis L, Doumtsis P, Tzoumari T, Akriviadis E, Cholongitas E Abstract INTRODUCTION AND AIM: Studies carried out mainly in patients with hepatocellular carcinoma (HCC), have shown the prognostic significance of albumin-bilirubin (ALBI) grade. Recently, another predictive score incorporating platelet count into ALBI, PALBI grade, was introduced in patients with HCC. AIM: We evaluated the ability of ALBI and PALBI grades in predicting the outcome (mortality / liver transplantation) of patients with stable decompensated cirrhosis with various etiology of liver diseases. MATERIAL AND METHO...