Periprosthetic hypoxia as consequence of TRPM7 mediated cobalt influx in osteoblasts

This study shows that chemical hypoxia originating from HIF‐1α upregulation within the periprosthetic tissue is related to cobalt wear debris and highlights TRPM7 as an important key mediator in this context. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 00B: 0 00–000, 2018.

Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - December 3, 2018 Category: Materials Science Authors: Constantin R ömmelt, Thomas Munsch, Andreas Drynda, Volkmar Lessmann, Christoph H. Lohmann, Jessica Bertrand Tags: Original Research Reports Source Type: research