Letrozole-associated controlled ovarian hyperstimulation in breast cancer patients versus conventional controlled ovarian hyperstimulation in infertile patients: assessment of oocyte quality related biomarkers.

CONCLUSIONS: Let-COH triggered with hCG may negatively impact oocyte quality. However, ovulation triggering with GnRHa may improve the oocyte microenvironment and cumulus cell genes expression in Let-COH, suggesting a positive impact on oocyte quality in breast cancer patients. TRIAL REGISTRATION: Clinicaltrials.gov - NCT02661932 , registered 25 January 2016, retrospectively registered. PMID: 30606204 [PubMed - in process]

https://www.ncbi.nlm.nih.gov/pubmed/30606204?dopt=Abstract

Source: Reproductive Biology - January 3, 2019 Category: Reproduction Medicine Authors: Goldrat O, Van Den Steen G, Gonzalez-Merino E, Dechène J, Gervy C, Delbaere A, Devreker F, De Maertelaer V, Demeestere I Tags: Reprod Biol Endocrinol Source Type: research