Diarylheptanoids with anti-inflammatory activity from the rhizomes of Pleuranthodium racemigerum (Zingiberaceae)

Publication date: April 2019Source: Phytochemistry Letters, Volume 30Author(s): Ritesh Raju, Ahilya Singh, Dhanushka Gunawardena, Paul Reddell, Gerald MünchAbstractThree new metabolites, 1-(4′′-Methoxyphenyl)-7-(3′,4′-di-hydroxyphenyl)-(E)-hept-2-ene (1), 1-(4′′-Methoxyphenyl)-7-(3′,4′-di-methoxyphenyl)-(E)-hept-2-ene (2), 1-(4′′-Methoxyphenyl)-7-(4′-methoxyphenyl)-(E)-hept-2-ene (3), and the known diaryl heptanoid (4) were identified following anti-inflammatory activity guided fractionation from the rhizomes of Pleuranthodium racemigerum (Zingiberaceae). These diaryl heptanoids (1 – 4) were evaluated for their inhibitory effects on NO production and downregulation of TNF-α in RAW 264.7 macrophages and N-11 microglial cell lines).Graphical abstract

Source: Phytochemistry Letters - January 6, 2019 Category: Chemistry Source Type: research