Regrowth and progression of multiple calcifying pseudoneoplasms of the neuraxis: Case report.

Conclusion: CAPNONs may indicate healing process associated with an unidentified agent. Maximum resection, including an unidentified agent, is necessary to prevent recurrence. PMID: 30603228 [PubMed]
Source: Surgical Neurology International - Category: Neurosurgery Tags: Surg Neurol Int Source Type: research

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Authors: Yin N, Xie T, Zhang H, Chen J, Yu J, Liu F Abstract Isocitrate dehydrogenase 1 (IDH1) is the most frequently mutated gene in World Health Organization grade II-III and secondary glioma. The majority of IDH1 mutation cases involve the substitution from arginine to histidine at codon 132 (IDH1-R132H). Although the oncogenic role of IDH1-R132H has been confirmed, patients with IDH1-R132H brain tumors exhibit a better response to radiotherapy compared with those with wild-type (WT) IDH1. In the present study, the potential mechanism of radiosensitization mediated by IDH1-R132H was investigated by overexpressin...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
Publication date: Available online 23 January 2020Source: MethodsAuthor(s): Jean de Montigny, Alexandros Iosif, Lukas Breitwieser, Marco Manca, Roman Bauer, Vasileios VavourakisAbstractThis paper develops a three-dimensional in silico hybrid model of cancer, which describes the multi-variate phenotypic behaviour of tumour and host cells. The model encompasses the role of cell migration and adhesion, the influence of the extracellular matrix, the effects of oxygen and nutrient availability, and the signalling triggered by chemical cues and growth factors. The proposed in silico hybrid modelling framework combines successful...
Source: Methods - Category: Molecular Biology Source Type: research
(Universitat Autonoma de Barcelona) An article published in Brain Communications, coordinated by Carlos Barcia, researcher at Institut de Neuroci è ncies de la UAB, describes how the immune system facilitates the expansion of tumor cells in the brain. The study was performed on human samples of glioblastoma, the most aggressive brain tumor, and on cell culture models. These findings will help to develop treatments for this type of tumor, for which there is not an effective therapy at the moment.
Source: EurekAlert! - Biology - Category: Biology Source Type: news
(Universitat Autonoma de Barcelona) An article published in Brain Communications, coordinated by Carlos Barcia, researcher at Institut de Neuroci è ncies de la UAB, describes how the immune system facilitates the expansion of tumour cells in the brain. The study was performed on human samples of glioblastoma, the most aggressive brain tumour, and on cell culture models. These findings will help to develop treatments for this type of tumour, for which there is not an effective therapy at the moment.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
Publication date: Available online 21 January 2020Source: Biocybernetics and Biomedical EngineeringAuthor(s): P.M. Siva Raja, Antony Viswasa raniAbstractIn medical image processing, brain tumor detection and segmentation is a challenging and time-consuming task. Magnetic Resonance Image (MRI) scan analysis is a powerful tool in the recent technology that makes effective detection of the abnormal tissues from the brain. In the brain image, the size of a tumor can be varied for different patients along with the minute details of the tumor. It is a difficult task to diagnose and classify the tumor from numerous images for the...
Source: Biocybernetics and Biomedical Engineering - Category: Biomedical Engineering Source Type: research
Conclusion: In gliomas, elevated circulating and CSF sPD-L1 levels are associated with aggressive biological activities. The results of the current study suggest that sPD-L1 is a promising biomarker for gliomas that can be used in clinical practice.
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Jovčevska Owing to the advancement of technology combined with our deeper knowledge of human nature and diseases, we are able to move towards precision medicine, where patients are treated at the individual level in concordance with their genetic profiles. Lately, the integration of nanoparticles in biotechnology and their applications in medicine has allowed us to diagnose and treat disease better and more precisely. As a model disease, we used a grade IV malignant brain tumor (glioblastoma). Significant improvements in diagnosis were achieved with the application of fluorescent nanoparticles for intraoperative mag...
Source: Molecules - Category: Chemistry Authors: Tags: Review Source Type: research
Authors: Navarro-Bonnet J, Suarez-Meade P, Brown DA, Chaichana KL, Quinones-Hinojosa A Abstract Gliomas are molecularly complex neoplasms and require a multidisciplinary approach to treatment. Maximal safe resection is often the initial goal of treatment and extent of resection (EOR) is an important prognostic factor correlating with both progression-free-survival (PFS) and overall survival (OS). Postoperative patient outcome is also a critical and independent prognosticator and high EOR must not be achieved at the expense of good functional outcome. Several intraoperative adjuvant techniques have been developed to...
Source: Journal of Neurosurgical Sciences - Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research
Authors: La Rocca G, Della Pepa GM, Menna G, Altieri R, Ius T, Rapisarda A, Olivi A, Sabatino G Abstract Achieving a safe and extensive neoplasm resection can be considered the main goal of brain tumor surgery. This paper is first aimed at providing an overview of the evolution of those tools serving the purpose. From the dawn of neurosurgery to the present days, major innovations have followed one another. However, those techniques may frequently lack of an instant biological feedback on the true extension and the infiltration of the tumor. Intraoperative fluorescence modalities could indeed fill this gap. Fluores...
Source: Journal of Neurosurgical Sciences - Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research
CONCLUSIONS: When dark corridors are presents or when overlying brain parenchyma hinders illumination, drawbacks to the 5-ALA assistance can be expected, hence CEUS final survey has a crucial role of 'refinement'. In those selected cases, an integrated 5ALA+CEUS protocol was shown as advisable in EOR improvement. PMID: 31961118 [PubMed - in process]
Source: Journal of Neurosurgical Sciences - Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research
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