Age-related deficits in intracortical myelination in young adults with bipolar disorder type I

In this study, we investigated whole-brain intracortical myelin (ICM) content in people with bipolar disorder type I and controls. Methods: Between Sept. 1, 2014, and Jan. 31, 2017, we used a 3 T General Electric scanner to collect T1-weighted images in 45 people with bipolar disorder type I and 60 controls aged 17 to 45 years using an optimized sequence that was sensitive to ICM content. We analyzed images using a surfacebased approach. We used general linear models with quadratic age terms to examine the signal trajectory of ICM across the age range. Results: In healthy controls, the T1-weighted signal followed an inverted-U trajectory over age; in people with bipolar disorder type I, the association between ICM and age followed a flat trajectory (p
Source: Journal of Psychiatry and Neuroscience - Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

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Publication date: October 2019Source: Epilepsy &Behavior, Volume 99Author(s): Ravindra Arya, Brian Ervin, Jonathan Dudley, Jason Buroker, Leonid Rozhkov, Craig Scholle, Paul S. Horn, Jennifer Vannest, Anna W. Byars, James L. Leach, Francesco T. Mangano, Hansel M. Greiner, Katherine D. Holland, Tracy A. GlauserAbstractObjectiveWe prospectively validated stereo-electroencephalography (EEG) electrical stimulation mapping (ESM) of language against a reference standard of meta-analytic functional magnetic resonance imaging (fMRI) framework (Neurosynth).MethodsLanguage ESM was performed using 50 Hz, biphasic, bipolar, stim...
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
Conclusion We recommend suture for hemostasis during laparoscopic cystectomy.Resumo Objetivo O objetivo desta revis ão foi comparar o impacto dos diferentes métodos hemostáticos na reserva ovariana durante a ooforoplastia laparoscópica. Fontes de Dados Os estudos foram identificados através da pesquisa de bases de dados eletrônicas (MEDLINE, Embase, Cochrane, LILACS) e listas de referência de artigos. S eleção dos estudos Selecionamos ensaios clínicos que avaliaram a influência das técnicas hemostáticas na reserva ovariana em pacientes ...
Source: Revista Brasileira de Ginecologia e Obstetricia - Category: OBGYN Source Type: research
ConclusionSG leaks can add long-term morbidity. Stent can be used successfully to treat SG leak if used judiciously. There should be low threshold for investigating patients with EWL of>  100% for anatomical complications like stricture, fistula or kink in the gastric sleeve. We wanted to make the bariatric fraternity aware of a rare late (>  12 weeks) complication of gastro-colic fistula after successfully treated SG leak. Limited literature is published about this rare complication and its management which ranges from conservative management to stent placement to surgical intervention (Asian Jour...
Source: Obesity Surgery - Category: Surgery Source Type: research
For more than a century, researchers have had a deeply-held belief that schizophrenia is one form of mental illness that has its basis in genetics. In the intervening years, hundreds of millions of person-hours and billions of dollars have been funneled pursuing the genetic theory of schizophrenia. Despite all of this enormous effort, researchers are starting to understand that perhaps the genetic component of schizophrenia has been overemphasized. And, in fact, the heritability estimates are not the 80-85 percent that some researchers claimed, but instead are far less. A new review article published in Psychiatry Researc...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: General Research Schizophrenia Causes Of Schizophrenia Schizophrenia Causes Source Type: blogs
Conclusion A small craniotomy around the superior temporal line provides an optimal window to evacuate an acute SDH and achieve hemostasis using an endoscope. Endoscopic evacuation of acute SDHs could be effective in selected cases. [...] Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text
Source: Journal of Neurological Surgery Part A: Central European Neurosurgery - Category: Neurosurgery Authors: Tags: Original Article Source Type: research
Purpose of review To give an update on recent imaging studies probing positron emission tomography (PET) as a tool for improving biomarker-guided diagnosis of neuropsychiatric disorders. Recent findings Several studies confirmed the value of imaging of regional neuronal activity and imaging of dopaminergic, serotonergic, and other neuroreceptor function in the diagnostic process of neuropsychiatric disorders, particularly schizophrenia, depression/bipolar disorder, substance use disorders, obsessive compulsive disorders (OCD), and attention-deficit/hyperactivity disorder. Additionally, imaging brain microglial activat...
Source: Current Opinion in Neurology - Category: Neurology Tags: NEUROIMAGING: Edited by Stefan Klöppel Source Type: research
Abstract OBJECTIVE: Bipolar disorders increase the risk of dementia and show biological and brain alterations, which resemble accelerated aging. Lithium may counter some of these processes and lower the risk of dementia. However, until now no study has specifically investigated the effects of Li on brain age. METHODS: We acquired structural magnetic resonance imaging scans from 84 participants with bipolar disorders (41 with and 43 without Li treatment) and 45 controls. We used a machine learning model trained on an independent sample of 504 controls to estimate the individual brain ages of study participants...
Source: The Australian and New Zealand Journal of Psychiatry - Category: Psychiatry Authors: Tags: Aust N Z J Psychiatry Source Type: research
Could the advancement of machine and deep learning algorithms be harnessed meaningfully in the area of mental health? Could depression, bipolar disorder, schizophrenia, or any other mental disorder be quantified so that technology could somehow add positively to their diagnostics or treatment? We tried to explore the uses of artificial intelligence in mental health care, and stumbled upon smart algorithms that support clinicians with early detection and diagnostics of mental health issues, with the flagging of suicide risks, and other ones that help patients manage their condition through counselling and constantly being t...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: Future of Medicine AI artificial intelligence bipolar disorder chatbots future of psychiatry mental disorder mental health mental health disorders mental health issues moodkit pacifica schizophrenia suicide thriveport woebot Source Type: blogs
CONCLUSION: In this exploratory study on a systemic comparison of thirteen ECT electrode placements, the EF magnitude at regions of interest (ROIs) was highly dependent upon the position of both electrodes, especially the ROIs close to the cortical surface. Compared to conventional right-unilateral (RUL) ECT using a temporo-parietal placement, fronto-parietal and supraorbito-parietal RUL also robustly stimulated brain regions considered important for efficacy, while sparing regions related to cognitive functions, and may be a preferrable approach to the currently used placement for RUL ECT. The simulations also found that ...
Source: Journal of the Association of European Psychiatrists - Category: Psychiatry Tags: Eur Psychiatry Source Type: research
Publication date: August 2019Source: European Psychiatry, Volume 60Author(s): Siwei Bai, Donel Martin, Tianruo Guo, Socrates Dokos, Colleen LooAbstractBackgroundElectroconvulsive therapy (ECT) is a highly effective treatment for severe psychiatric disorders. Despite its high efficacy, the use of ECT would be greater if the risk of cognitive side effects were reduced. Over the last 20 years, developments in ECT technique, including improvements in the dosing methodology and modification of the stimulus waveform, have allowed for improved treatment methods with reduced adverse cognitive effects. There is increasing evidence ...
Source: European Psychiatry - Category: Psychiatry Source Type: research
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