Indole-2-carboxamides are Active Against an Acute Mycobacterium abscessus Infected Mouse Model.

This study discloses in vivo data for two lead molecules (5 and 25) that were advanced for efficacy studies in Mycobacterium abscessus infected mouse models. Oral administration of the lead molecules showed a statistically significant reduction in the bacterial load in lung and spleen of M. abscessus-infected mice.
PMID: 30602519 [PubMed - as supplied by publisher]

Source: Antimicrobial Agents and Chemotherapy - January 2, 2019 Category: Microbiology Authors: Pandya AN, Prathipati PK, Hegde P, Li W, Graham KF, Mandal S, Drescher KM, Destache CJ, Ordway D, Jackson M, North EJ Tags: Antimicrob Agents Chemother Source Type: research