Efficacy and safety of pyronaridine-artesunate plus single-dose primaquine for the treatment of uncomplicated Plasmodium falciparum malaria in eastern Cambodia.

Efficacy and safety of pyronaridine-artesunate plus single-dose primaquine for the treatment of uncomplicated Plasmodium falciparum malaria in eastern Cambodia. Antimicrob Agents Chemother. 2019 Jan 02;: Authors: Leang R, Mairet-Khedim M, Chea H, Huy R, Khim N, Mey Bouth D, Dorina Bustos M, Ringwald P, Witkowski B Abstract In Cambodia, multi-drug resistant Plasmodium falciparum undermines the treatment of uncomplicated malaria and new therapeutic options are needed. Pyronaridine-artesunate has not previously been evaluated in eastern Cambodia. This single-arm, open-label, prospective study was conducted July-December 2017 at Koh Gnek (Mondulkiri) and Veun Sai (Rattanakiri) health centers in eastern Cambodia. Eligible patients were aged ≥7 years (females 12-18 years excluded), weighing ≥20 kg, with microscopically confirmed P. falciparum mono-infection and fever. Oral pyronaridine-artesunate was administered once daily for three days, dosed according to body weight, plus a single dose of primaquine on day 0. Sixty patients were recruited to Koh Gnek, 61 to Veun Sai. The primary outcome, day 42 PCR-adjusted adequate clinical and parasitological response (ACPR) was 98.3% (95% CI 88.4-99.8) in Koh Gnek and 96.7% (95% CI 87.3-99.2) in Veun Sai (Kaplan-Meier). In a per-protocol analysis, the proportion of patients with day 42 PCR-adjusted ACPR was 98.3% ([57/58] 95% CI 90.8-100.0) at Koh Gnek and 96.7% ([58/60] 95% CI 88.5-99.6) at Veu...
Source: Antimicrobial Agents and Chemotherapy - Category: Microbiology Authors: Tags: Antimicrob Agents Chemother Source Type: research